Guo Honghao, Zhang Ning, Huang Tao, Shen Na
Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
Int J Mol Sci. 2025 Jan 16;26(2):710. doi: 10.3390/ijms26020710.
MicroRNA-200c (miR-200c) is increasingly recognized as a crucial small RNA molecule that plays a significant and multifaceted role in the complex processes of tumor development, invasion, and metastasis across various types of cancers. Recent studies have compellingly demonstrated that miR-200c exerts its influence on tumor biology by meticulously regulating a range of critical processes, including cell proliferation, apoptosis, epithelial-mesenchymal transition (EMT), and cell migration, all of which are essential for the progression and aggressiveness of tumors. This comprehensive review aims to summarize the expression characteristics and functional implications of miR-200c across a diverse array of tumor types, delving into its potential utility as both a biomarker for early detection and a therapeutic target in the realm of cancer treatment. By synthesizing current research findings and insights, we aspire to provide valuable information that could significantly enhance early diagnostic capabilities and inform the strategic development of targeted therapy approaches in oncology.
微小RNA - 200c（miR - 200c）日益被视为一种关键的小RNA分子，在各类癌症的肿瘤发生、侵袭和转移等复杂过程中发挥着重要且多方面的作用。近期研究有力地表明，miR - 200c通过精确调控一系列关键过程来影响肿瘤生物学，这些过程包括细胞增殖、凋亡、上皮 - 间质转化（EMT）和细胞迁移，所有这些对于肿瘤的进展和侵袭性都至关重要。这篇全面综述旨在总结miR - 200c在多种肿瘤类型中的表达特征和功能意义，深入探讨其作为早期检测生物标志物和癌症治疗领域治疗靶点的潜在效用。通过综合当前的研究结果和见解，我们希望提供有价值的信息，这可能显著提高早期诊断能力，并为肿瘤学中靶向治疗方法的战略发展提供参考。
