Canfield L M, Davy L A, Thomas G L
Biochem Biophys Res Commun. 1985 Apr 16;128(1):211-9. doi: 10.1016/0006-291x(85)91666-3.
Experiments were designed to measure O2 consumption caused by the oxidation of linoleic acid. These experiments show that vitamin K has antioxidant activity and that the reduction in linoleic acid oxidation is directly dependent upon vitamin K concentration. Conversely, vitamin K hydroquinone enhances linoleic acid oxidation in the absence of iron catalyst, again in a concentration dependent manner. At equilmolar concentrations vitamin K is about 80% as effective as vitamin E as an antioxidant. Vitamin E inhibits the oxidation of linoleic acid catalyzed by vitamin K hydroquinone. Vitamin E also strongly inhibits vitamin K dependent formation of both vitamin K epoxide and gamma-carboxyglutamic acid (gla). The significance of these observations to vitamin K action in vivo is discussed.
实验旨在测量由亚油酸氧化引起的氧气消耗。这些实验表明，维生素K具有抗氧化活性，亚油酸氧化的减少直接取决于维生素K的浓度。相反，在没有铁催化剂的情况下，维生素K对苯二酚以浓度依赖的方式增强亚油酸氧化。在等摩尔浓度下，维生素K作为抗氧化剂的效果约为维生素E的80%。维生素E抑制维生素K对苯二酚催化的亚油酸氧化。维生素E还强烈抑制维生素K依赖性维生素K环氧化物和γ-羧基谷氨酸（gla）的形成。讨论了这些观察结果对维生素K在体内作用的意义。
