Liu Chun-Hung, Chen Jeon-Hor, Westphalen Antonio Carlos, Chen Chun-Ming, Chang Chih-Ping, Lin Wei-Ching
Department of Medical Imaging, China Medical University Hospital, Taichung 40402, Taiwan.
Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung 82445, Taiwan.
Life (Basel). 2025 Jan 9;15(1):73. doi: 10.3390/life15010073.
Blood pressure measurement is important in monitoring hypertension. However, blood pressure does not provide much information about renal condition in treated hypertension. This study aimed to evaluate renal oxygenation in hypertensive patients using T2* mapping. Subgroup analysis explored whether R2* values can guide adjustments in antihypertensive treatment. A total of 140 consecutive subjects were recruited: 87 hypertensive subjects and 53 normotensive subjects. Hypertensive subjects were classified into non-medication (non-med), angiotensin II receptor blocker (ARB), and non-ARB-treated groups. Each group was divided into good and poor control subgroups based on blood pressure at enrollment. T2* mapping was utilized to assess renal cortical and medullary R2* values. After a 2-year follow-up, subjects were categorized into stable and unstable based on the need for treatment modifications. The unstable subgroup had higher medullary R2* values than the stable subgroup in all followed patients ( < 0.05). Additionally, the unstable merged non-med with ARB subgroup had higher medullary R2* values overall ( < 0.05) and within the good control subgroup ( < 0.05). Patients with stable hypertension, especially those with good control managed through lifestyle modifications or ARBs, exhibited lower renal medullary R2* values, suggesting higher renal oxygenation.
血压测量在监测高血压方面很重要。然而，血压并不能提供太多关于已治疗高血压患者肾脏状况的信息。本研究旨在使用T2* 映射评估高血压患者的肾脏氧合情况。亚组分析探讨了R2* 值是否可以指导抗高血压治疗的调整。共招募了140名连续受试者：87名高血压受试者和53名血压正常的受试者。高血压受试者被分为未用药组（非用药组）、血管紧张素II受体阻滞剂（ARB）组和非ARB治疗组。根据入组时的血压，每组又分为控制良好和控制不佳的亚组。利用T2* 映射评估肾皮质和髓质的R2* 值。经过2年的随访，根据治疗调整的需要将受试者分为稳定组和不稳定组。在所有随访患者中，不稳定亚组的髓质R2* 值高于稳定亚组（<0.05）。此外，不稳定合并的非用药组与ARB组总体上（<0.05）以及在控制良好的亚组内（<0.05）髓质R2* 值更高。血压稳定的患者，尤其是那些通过生活方式改变或ARB实现良好控制的患者，肾髓质R2* 值较低，提示肾脏氧合较高。
