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前庭神经鞘瘤的临床表现、治疗结果及人口统计学趋势：一项135例回顾性研究

Clinical Presentation, Treatment Outcomes, and Demographic Trends in Vestibular Schwannomas: A 135-Case Retrospective Study.

作者信息

Toader Corneliu, Rădoi Petrinel Mugurel, Ilie Milena-Monica, Covache-Busuioc Razvan-Adrian, Buica Vlad, Glavan Luca-Andrei, Serban Matei, Corlatescu Antonio Daniel, Crivoi Carla, Gorgan Radu Mircea

机构信息

Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania.

出版信息

J Clin Med. 2025 Jan 14;14(2):482. doi: 10.3390/jcm14020482.

DOI:10.3390/jcm14020482
PMID:39860488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11766384/
Abstract

: This study presents a comprehensive analysis of 135 cases of vestibular schwannoma (VS) treated between 2006 and 2022 at the National Institute of Neurology and Neurovascular Diseases in Bucharest, Romania. The investigation focuses on the clinical presentation, treatment outcomes, and demographic trends of VS patients, highlighting region-specific insights that fill critical gaps in Eastern European data. : Patients were treated with either open surgery (93.3%) or gamma knife radiosurgery (6.6%). The study identifies predominant symptoms, including hearing impairment, facial palsy, and balance disorders, with variations observed across age and gender subgroups. Comorbidities such as hypertension and obesity were prevalent, and they influenced perioperative risks. : Post-treatment outcomes showed a significant correlation between clinical symptoms and treatment modalities, with a majority achieving favorable results. The findings emphasize the need for tailored approaches in VS management and underscore the importance of region-specific factors in influencing clinical outcomes. : This study contributes to refining treatment strategies and improving healthcare delivery for VS patients in Romania and beyond.

摘要

本研究对2006年至2022年期间在罗马尼亚布加勒斯特国家神经病学和神经血管疾病研究所接受治疗的135例前庭神经鞘瘤（VS）患者进行了全面分析。该调查聚焦于VS患者的临床表现、治疗结果和人口统计学趋势，突出了填补东欧数据关键空白的特定区域见解。患者接受了开放手术（93.3%）或伽玛刀放射外科治疗（6.6%）。该研究确定了主要症状，包括听力障碍、面神经麻痹和平衡障碍，在不同年龄和性别亚组中观察到了差异。高血压和肥胖等合并症很常见，它们影响围手术期风险。治疗后的结果显示临床症状与治疗方式之间存在显著相关性，大多数患者取得了良好的效果。研究结果强调了在VS管理中采用量身定制方法的必要性，并强调了特定区域因素对临床结果的影响。这项研究有助于完善罗马尼亚及其他地区VS患者的治疗策略并改善医疗服务。

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