Karabay Gulsan, Bayraktar Burak, Seyhanli Zeynep, Filiz Ahmet Arif, Tokgoz Cakir Betul, Aktemur Gizem, Tonyali Nazan Vanli, Agaoglu Recep Taha, Kocaoglu Gulcan, Karabay Umut, Yucel Kadriye Yakut
Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara 06170, Turkey.
Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, Ankara 06170, Turkey.
J Clin Med. 2025 Jan 20;14(2):647. doi: 10.3390/jcm14020647.
: The aim of this study was to examine the relationship between conventional and novel Doppler parameters, including cerebroplacental ratio (CPR), cerebral-placental-uterine ratio (CPUR), umbilical-to-cerebral ratio (UCR), and amniotic-to-umbilical-cerebral ratio (AUCR), with the diagnosis of preeclampsia (PE) and adverse neonatal outcomes in PE cases. : This prospective case-control study was conducted at the Ankara Etlik City Hospital Perinatology Clinic between November 2023 and May 2024. The study population was divided into two groups: Group 1, consisting of 74 patients diagnosed with preeclampsia, and Group 2, consisting of 80 healthy control patients. Composite adverse perinatal outcomes (CANOs) include presence of at least one adverse outcome: 5th-minute APGAR score < 7, transient tachypnea of the newborn (TTN), respiratory distress syndrome (RDS), need for continuous positive airway pressure (CPAP), need for mechanical ventilation, neonatal intensive care unit (NICU) admission, neonatal hypoglycemia, need for phototherapy, intraventricular hemorrhage (IVH), and neonatal sepsis. : The CPR, CPUR, and AUCR were significantly lower in the PE group compared to the control group, while the UCR was notably higher in the PE group. Among the combined ratios, the CPUR exhibited the highest diagnostic performance for both PE diagnosis and the prediction of CANOs. Additionally, while the UCR, CPR, and AUCR were significant for PE diagnosis, only AUCR demonstrated a significant association with the prediction of CANOs. : Combined Doppler parameters, especially CPUR and AUCR, offer valuable insights into diagnosing PE and predicting CANOs. CPUR demonstrated the highest diagnostic accuracy, underscoring its potential utility in clinical settings.
本研究的目的是探讨传统和新型多普勒参数，包括脑胎盘比率（CPR）、脑胎盘子宫比率（CPUR）、脐脑比率（UCR）和羊膜与脐脑比率（AUCR），与子痫前期（PE）的诊断以及PE病例中不良新生儿结局之间的关系。 这项前瞻性病例对照研究于2023年11月至2024年5月在安卡拉埃特利克市立医院围产医学诊所进行。研究人群分为两组：第1组由74例诊断为子痫前期的患者组成，第2组由80例健康对照患者组成。复合不良围产期结局（CANOs）包括至少出现一种不良结局：出生后5分钟阿氏评分＜7、新生儿短暂性呼吸急促（TTN）、呼吸窘迫综合征（RDS）、需要持续气道正压通气（CPAP）、需要机械通气、入住新生儿重症监护病房（NICU）、新生儿低血糖、需要光疗、脑室内出血（IVH）和新生儿败血症。 与对照组相比，PE组的CPR、CPUR和AUCR显著降低，而PE组的UCR显著升高。在综合比率中，CPUR在PE诊断和CANOs预测方面均表现出最高的诊断性能。此外，虽然UCR、CPR和AUCR对PE诊断有显著意义，但只有AUCR与CANOs预测有显著关联。 联合多普勒参数，尤其是CPUR和AUCR，为诊断PE和预测CANOs提供了有价值的见解。CPUR表现出最高的诊断准确性，突出了其在临床环境中的潜在效用。
