Xia Yuxiang, Wang Xinrui, Guo Zhe, Wang Xuesong, Wang Zhong
School of Clinical Medicine, Tsinghua University, 30 Shuangqing Road, Haidian District Beijing, Beijing 102218, China.
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, 168 Litang Road, Changping District, Beijing 102218, China.
Sensors (Basel). 2025 Jan 8;25(2):330. doi: 10.3390/s25020330.
(1) Background: To develop a novel capillary refill time measurement system and evaluate its reliability and reproducibility. (2) Methods: Firstly, the utilization of electromagnetic pressure technology facilitates the automatic compression and instantaneous release of the finger. Secondly, the employment of pressure sensing technology and photoelectric volumetric pulse wave analysis technology enables the dynamic monitoring of blood flow in distal tissues. Thirdly, the subjects were recruited to compare the average measurement time and the number of measurements required for successful measurements. The satisfaction of doctors and patients with the instrument was investigated through the administration of questionnaires. Finally, 71 subjects were recruited and divided into two groups, A and B. Three doctors repeated the measurement of the right index fingers of the subjects. In Group A, the same measuring instrument was used, and the consistency of the measurements was evaluated using the intragroup correlation coefficient. In Group B, one doctor repeated the measurement of each subject three times using the same measuring instrument, and the reproducibility of the CRT was evaluated using the analysis of variance of the repeated measurement data. (3) Results: The development of the capillary refill time meter was successful, with an average measurement time of 18 s and a single measurement. This study found that doctor-patient satisfaction levels were 98.3% and 100%, respectively. The intraclass correlation coefficient was 0.995 in Group A, and the -value was greater than 0.05 in Group B. (4) Conclusions: The non-invasive monitoring of microcirculation has been rendered both rapid and effective, thus paving the way for the further mechanization and standardization of this process. The CRT, when measured using the capillary refill time meter test machine, demonstrated consistent and reproducible results, both when assessed by different researchers and when evaluated across varying measurement sets.
(1) 背景：开发一种新型的毛细血管再充盈时间测量系统，并评估其可靠性和可重复性。(2) 方法：首先，利用电磁压力技术实现手指的自动加压和瞬间释放。其次，采用压力传感技术和光电容积脉搏波分析技术对远端组织血流进行动态监测。第三，招募受试者比较平均测量时间和成功测量所需的测量次数。通过问卷调查医生和患者对该仪器的满意度。最后，招募71名受试者并分为A、B两组。三位医生对受试者的右手食指进行重复测量。A组使用同一测量仪器，采用组内相关系数评估测量的一致性。B组由一位医生使用同一测量仪器对每位受试者重复测量三次，采用重复测量数据的方差分析评估CRT的可重复性。(3) 结果：毛细血管再充盈时间测量仪研制成功，单次测量平均时间为18秒。本研究发现医生和患者的满意度分别为98.3%和100%。A组组内相关系数为0.995，B组P值大于0.05。(4) 结论：微循环的无创监测已变得快速有效，为该过程的进一步机械化和标准化铺平了道路。使用毛细血管再充盈时间测量仪测试机测量CRT时，不同研究者评估以及不同测量组评估均显示结果一致且具有可重复性。
