He Xiaoe, Jiang Xiangyan, Guo Jiayin, Sun Hui, Yang Jing
Cuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, China.
Pathogens. 2025 Jan 8;14(1):43. doi: 10.3390/pathogens14010043.
PANoptosis is a newly identified programmed cell death pathway that integrates characteristics of apoptosis, pyroptosis, and necroptosis. It plays a dual role in the host immune response to bacterial infections. On one hand, PANoptosis acts as a protective mechanism by inducing the death of infected cells to eliminate pathogens and releasing pro-inflammatory cytokines to amplify the immune response. On the other hand, bacteria can exploit PANoptosis to evade host immune defenses. This dual nature underscores the potential of PANoptosis as a target for developing novel therapies against bacterial infections. This review summarizes the molecular mechanisms of PANoptosis, along with the crosstalk and integration of different cell death pathways in response to various bacterial pathogens. We also discuss the dual roles of PANoptosis in bacterial infectious diseases, including sepsis, pulmonary infections, and intestinal infections. Elucidating the molecular mechanisms underlying PANoptosis and how bacteria manipulate this pathway offers critical insights into host-pathogen interactions. These insights provide a foundation for designing targeted antibacterial strategies, modulating inflammation, and advancing precision medicine to improve clinical outcomes.
PANoptosis是一种新发现的程序性细胞死亡途径，整合了凋亡、焦亡和坏死性凋亡的特征。它在宿主对细菌感染的免疫反应中发挥双重作用。一方面，PANoptosis通过诱导受感染细胞死亡以清除病原体并释放促炎细胞因子来放大免疫反应，从而起到保护机制的作用。另一方面，细菌可以利用PANoptosis来逃避宿主的免疫防御。这种双重性质凸显了PANoptosis作为开发新型抗细菌感染疗法靶点的潜力。本综述总结了PANoptosis的分子机制，以及不同细胞死亡途径在应对各种细菌病原体时的相互作用和整合。我们还讨论了PANoptosis在包括败血症、肺部感染和肠道感染在内的细菌感染性疾病中的双重作用。阐明PANoptosis的分子机制以及细菌如何操纵这一途径，为深入了解宿主-病原体相互作用提供了关键见解。这些见解为设计靶向抗菌策略、调节炎症以及推进精准医学以改善临床结果奠定了基础。
