Hassan Hesham M, Hassan Roket, Elmagzoub Ranya Mohammed, Al-Emam Ahmed, Kossenas Konstantinos, Abdel-Samea Ahmed S, Khalifa Hazim O, Akocak Suleyman, Bräse Stefan, Hashem Hamada
Department of Pathology, College of Medicine, King Khalid University, Asir 61421, Saudi Arabia.
Department of Pathology, Faculty of Medicine, Assiut University, Assiut 71111, Egypt.
Pharmaceuticals (Basel). 2025 Jan 9;18(1):72. doi: 10.3390/ph18010072.
Ciprofloxacin, a widely used second-generation fluoroquinolone for treating bacterial infections, has recently shown notable anticancer properties. This review explores progress in developing ciprofloxacin derivatives with anticancer properties, emphasizing key structural changes that improve their therapeutic effectiveness by modifying the basic group at position 7, the carboxylic acid group at position 3, or both. It further investigates the mechanisms by which these derivatives fight cancer, such as inducing apoptosis, arresting the cell cycle, inhibiting topoisomerase I and II, preventing tubulin polymerization, suppressing interleukin 6, blocking thymidine phosphorylase, inhibiting multidrug resistance proteins, and hindering angiogenesis. Additionally, it outlines their future directions, such as enhancing their efficacy, selectivity, and investigating potential synergy with other chemotherapeutic agents, offering a promising avenue for developing new therapies for cancer.
环丙沙星是一种广泛用于治疗细菌感染的第二代氟喹诺酮类药物，最近显示出显著的抗癌特性。本综述探讨了具有抗癌特性的环丙沙星衍生物的开发进展，重点强调了通过修饰7位的碱性基团、3位的羧酸基团或两者来改善其治疗效果的关键结构变化。它进一步研究了这些衍生物对抗癌症的机制，如诱导细胞凋亡、阻断细胞周期、抑制拓扑异构酶I和II、防止微管蛋白聚合、抑制白细胞介素6、阻断胸苷磷酸化酶、抑制多药耐药蛋白以及阻碍血管生成。此外，还概述了它们的未来发展方向，如提高疗效、选择性以及研究与其他化疗药物的潜在协同作用，为开发新的癌症治疗方法提供了一条有前景的途径。
