Tseng Hsiang-Kuang, Cheng Yun-Ju, Yu Hui-Kung, Chou Kuan-Ting, Pang Chin-Yen, Hu Gwo-Chi
Division of Geriatric Medicine, Department of Internal Medicine, MacKay Memorial Hospital, Taipei 104217, Taiwan.
Department of Medicine, MacKay Medical College, New Taipei City 252005, Taiwan.
Nutrients. 2025 Jan 8;17(2):221. doi: 10.3390/nu17020221.
Malnutrition and frailty are independent risk factors of prolonged hospitalization and mortality, respectively. However, the combined association of these conditions with the risk of prolonged hospitalization and mortality in hospitalized elderly patients remains unclear. Our object was to investigate the combined association of malnutrition and frailty on the risk of prolonged hospitalization and mortality in hospitalized elderly patients. : The current study was a retrospective analysis of 470 patients admitted to the geriatric care unit of a tertiary hospital in Taiwan between 01 August 2019 and 31 March 2023. The Mini Nutritional Assessment-short form and Clinical Frailty Scale were used as evaluation tools for nutritional and frailty status, respectively. Patients were divided into four groups based on nutritional and frailty status. The association between these conditions and the risk of prolonged hospitalization and mortality was investigated using multivariate logistic and Cox proportional hazard models and adjusting for potential confounders. : Among 470 patients, 144 (31%) exhibited no malnutrition risk or frailty, 146 (31%) exhibited malnutrition risk but no frailty, 46 (10%) exhibited frailty but no malnutrition risk, and 134 (28%) exhibited both malnutrition risk and frailty. Compared to patients with neither condition, those with both conditions had higher risks of prolonged hospitalization (odds ratio 3.23, 95% confidence interval [CI] 1.68-6.12) and mortality (hazard ratio 4.33; 95% CI 2.01-9.34). : The co-occurrence of malnutrition and frailty has significant detrimental impacts on the risk of prolonged hospitalization and mortality in hospitalized older adults. The findings of this study emphasize the importance of early screening and intervention for malnutrition and frailty among hospitalized elderly patients.
营养不良和身体虚弱分别是住院时间延长和死亡的独立危险因素。然而，这些状况与住院老年患者住院时间延长和死亡风险之间的联合关联仍不明确。我们的目的是研究营养不良和身体虚弱与住院老年患者住院时间延长和死亡风险之间的联合关联。：本研究是对2019年8月1日至2023年3月31日期间入住台湾一家三级医院老年护理病房的470例患者进行的回顾性分析。简易营养评估简表和临床衰弱量表分别用作营养和衰弱状况的评估工具。根据营养和衰弱状况将患者分为四组。使用多变量逻辑回归和Cox比例风险模型，并对潜在混杂因素进行调整，研究这些状况与住院时间延长和死亡风险之间的关联。：在470例患者中，144例（31%）无营养不良风险或身体虚弱，146例（31%）有营养不良风险但无身体虚弱，46例（10%）有身体虚弱但无营养不良风险，134例（28%）既有营养不良风险又有身体虚弱。与两种状况都没有的患者相比，两种状况都有的患者住院时间延长的风险更高（比值比3.23，95%置信区间[CI]1.68 - 6.12），死亡风险更高（风险比4.33；95%CI 2.01 - 9.34）。：营养不良和身体虚弱的共同出现对住院老年人住院时间延长和死亡风险有显著的不利影响。本研究结果强调了对住院老年患者营养不良和身体虚弱进行早期筛查和干预的重要性。
