Uttreja Prateek, Karnik Indrajeet, Adel Ali Youssef Ahmed, Narala Nagarjuna, Elkanayati Rasha M, Baisa Srikanth, Alshammari Nouf D, Banda Srikanth, Vemula Sateesh Kumar, Repka Michael A
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Pharmaceutics. 2025 Jan 5;17(1):63. doi: 10.3390/pharmaceutics17010063.
Self-emulsifying drug delivery systems (SEDDS) represent an innovative approach to improving the solubility and bioavailability of poorly water-soluble drugs, addressing significant challenges associated with oral drug delivery. This review highlights the advancements and applications of SEDDS, including their transition from liquid to solid forms, while addressing the formulation strategies, characterization techniques, and future prospects in pharmaceutical sciences. The review systematically analyzes existing studies on SEDDS, focusing on their classification into liquid and solid forms and their preparation methods, including spray drying, hot-melt extrusion, and adsorption onto carriers. Characterization techniques such as droplet size analysis, dissolution studies, and solid-state evaluations are detailed. Additionally, emerging trends, including 3D printing, hybrid systems, and supersaturable SEDDS (Su-SEDDS), are explored. Liquid SEDDS (L-SEDDS) enhance drug solubility and absorption by forming emulsions upon contact with gastrointestinal fluids. However, they suffer from stability and leakage issues. Transitioning to solid SEDDS (S-SEDDS) has resolved these limitations, offering enhanced stability, scalability, and patient compliance. Innovations such as personalized 3D-printed SEDDS, biologics delivery, and targeted systems demonstrate their potential for diverse therapeutic applications. Computational modeling and in silico approaches further accelerate formulation optimization. SEDDS have revolutionized drug delivery by improving bioavailability and enabling precise, patient-centric therapies. While challenges such as scalability and excipient toxicity persist, emerging technologies and multidisciplinary collaborations are paving the way for next-generation SEDDS. Their adaptability and potential for personalized medicine solidify their role as a cornerstone in modern pharmaceutical development.
自乳化药物递送系统（SEDDS）是一种创新方法，用于提高难溶性药物的溶解度和生物利用度，解决与口服药物递送相关的重大挑战。本综述重点介绍了SEDDS的进展和应用，包括它们从液体形式向固体形式的转变，同时阐述了药物科学中的制剂策略、表征技术和未来前景。该综述系统地分析了关于SEDDS的现有研究，重点关注其分为液体和固体形式的分类以及制备方法，包括喷雾干燥、热熔挤出和吸附到载体上。详细介绍了诸如液滴尺寸分析、溶出度研究和固态评估等表征技术。此外，还探讨了新兴趋势，包括3D打印、混合系统和过饱和SEDDS（Su-SEDDS）。液体SEDDS（L-SEDDS）通过与胃肠液接触形成乳液来提高药物溶解度和吸收。然而，它们存在稳定性和渗漏问题。向固体SEDDS（S-SEDDS）的转变解决了这些局限性，提供了增强的稳定性、可扩展性和患者顺应性。诸如个性化3D打印SEDDS、生物制剂递送和靶向系统等创新展示了它们在多种治疗应用中的潜力。计算建模和计算机模拟方法进一步加速了制剂优化。SEDDS通过提高生物利用度并实现精确的、以患者为中心的治疗，彻底改变了药物递送。虽然诸如可扩展性和辅料毒性等挑战仍然存在，但新兴技术和多学科合作正在为下一代SEDDS铺平道路。它们的适应性和个性化医疗潜力巩固了它们作为现代药物开发基石的地位。
