Maharajah's College of Pharmacy, Vizianagaram, Andhra Pradesh, India; GITAM Institute of Pharmacy, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India.
GITAM Institute of Pharmacy, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India.
Crit Rev Ther Drug Carrier Syst. 2021;38(2):27-74. doi: 10.1615/CritRevTherDrugCarrierSyst.2020034975.
Self-emulsifying drug delivery system (SEDDS), a category of lipid-based technology, has gained interest in the recent years for enhancement of solubility and bioavailability of poorly water-soluble drugs. With the progress of research in this field, novel excipients have been developed with enhanced properties. But excipient selection is the key hurdle in the formulation of SEDDS. The objective of this review is to summarize different types of oils, surfactants, co-surfactants which are the key components of liquid SEDDS (L-SEDDS), various carriers utilized in the conversion of L-SEDDS to solid SEDDS (S-SEDDS), their description, properties, grades, and applications in pharmacy. This article provides an overview of solidification techniques to transform L-SEDDS to S-SEDDS which are more stable and have better patience compliance. This review presents numerous literature reports on various excipients used and the discussion on how these excipients affect the final results.
自乳化药物传递系统（SEDDS）是一种基于脂质的技术类别，近年来因其可提高疏水性差的药物的溶解度和生物利用度而受到关注。随着该领域研究的进展，新型辅料已得到开发，并具有增强的性能。但辅料选择是 SEDDS 配方中的关键障碍。本文的目的是总结不同类型的油、表面活性剂、助表面活性剂，它们是液体 SEDDS（L-SEDDS）的关键成分，以及用于将 L-SEDDS 转化为固体 SEDDS（S-SEDDS）的各种载体，它们的描述、性质、等级和在药学中的应用。本文概述了将 L-SEDDS 转化为 S-SEDDS 的固化技术，这些技术更稳定，患者顺应性更好。本文综述了大量关于所用各种赋形剂的文献报告，并讨论了这些赋形剂如何影响最终结果。
