Gambadauro Antonella, Mollica Salvatore, Rosa Emanuela, Xerra Federica, Li Pomi Alessandra, Valenzise Mariella, Messina Maria Francesca, Vitale Agata, Gitto Eloisa, Wasniewska Malgorzata, Zirilli Giuseppina, Manti Sara
Pediatric Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy.
Faculty of Medicine and Surgery, University of Messina, Piazza Pugliatti 1, 98122 Messina, Italy.
Viruses. 2025 Jan 9;17(1):77. doi: 10.3390/v17010077.
Bronchiolitis is the most common cause of lower respiratory tract infection (LRTI) in the first year of life. We analyzed the association between complete blood count (CBC), c-reactive protein (CRP), and novel inflammatory indexes (NLR, PLR, MLR, ELR, LMR, NPR, LPR, LNR, PNR, SII, SIRI) in predicting bronchiolitis severity at hospital admission.
We retrospectively collected data from 95 infants hospitalized for bronchiolitis in a third-level hospital during three epidemic seasons. Five outcomes of severity were analyzed: BRAS; pediatric intensive care unit (PICU) admission; ventilatory support; intravenous (IV) rehydration; and length of stay (LOS).
Lower age and weight at admission were statistically associated with four of the five severity outcomes. Prolonged LOS (≥6 days) was associated with high values of total white blood cells, lymphocytes, and eosinophils. Only three inflammatory indexes (PLR, MLR, and PNR) showed a significant association with one outcome (prolonged LOS). A new index (RBC/AiW/1000) was statistically associated with each severity outcome for a value > 350.
We proposed a comprehensive analysis of the association between CBC, CRP, and novel inflammatory indexes and bronchiolitis severity. RBC/AiW/1000 could represent a future predictive marker of disease severity at hospital admission in infants with bronchiolitis.
细支气管炎是一岁以内儿童下呼吸道感染（LRTI）最常见的病因。我们分析了全血细胞计数（CBC）、C反应蛋白（CRP）以及新型炎症指标（中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）、嗜酸性粒细胞与淋巴细胞比值（ELR）、淋巴细胞与单核细胞比值（LMR）、中性粒细胞与血小板比值（NPR）、淋巴细胞与血小板比值（LPR）、淋巴细胞与中性粒细胞比值（LNR）、血小板与中性粒细胞比值（PNR）、全身炎症反应指数（SII）、全身炎症反应与免疫抑制指数（SIRI））在预测细支气管炎患儿入院时病情严重程度方面的相关性。
我们回顾性收集了一家三级医院在三个流行季节因细支气管炎住院的95例婴儿的数据。分析了五个严重程度结局：布拉斯评分（BRAS）；儿科重症监护病房（PICU）入院；通气支持；静脉补液；住院时间（LOS）。
入院时年龄和体重较低与五个严重程度结局中的四个在统计学上相关。住院时间延长（≥6天）与白细胞总数、淋巴细胞和嗜酸性粒细胞的高值相关。只有三个炎症指标（PLR、MLR和PNR）与一个结局（住院时间延长）显示出显著相关性。一个新指标（红细胞/人工智能白细胞/1000）在值>350时与每个严重程度结局在统计学上相关。
我们建议对CBC、CRP和新型炎症指标与细支气管炎严重程度之间的相关性进行综合分析。红细胞/人工智能白细胞/1000可能代表未来细支气管炎患儿入院时疾病严重程度的预测标志物。
