Ji Dandan, Sheng Mingyan, Zhang Liuyan, Han Yonggui, Jiang Qi, Ruan Qiongxiao
Department of Obstetrics, Beilun District People's Hospital, Ningbo, Zhejiang, China.
Department of Obstetrics and Gynecology, The Third Hospital of Beilun District, Ningbo, Zhejiang, China.
Br J Hosp Med (Lond). 2025 Jan 24;86(1):1-10. doi: 10.12968/hmed.2024.0543. Epub 2025 Jan 9.
Intrahepatic cholestasis of pregnancy (ICP) is associated with adverse perinatal outcomes, yet the correlation between ICP and the neutrophil-to-lymphocyte ratio (NLR) remains unclear. This study aims to investigate the diagnostic value of NLR in ICP. In this retrospective case-control study, 113 patients with ICP treated in Beilun District People's Hospital from January 2020 to December 2022 were recruited and categorized as the ICP group, and 209 healthy pregnant women treated during the same period were selected as the control group. The levels of NLR and mean platelet volume (MPV) were compared between the two groups. The NLR of patients with different ICP severity were compared. Logistic regression model was used to analyze the relationship between relevant indicators and ICP. The capability of NLR in predicting ICP was evaluated using receiver operating characteristic (ROC) curves. There were significant differences in age, neutrophil count, lymphocyte count, platelet count, MPV, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), NLR, and serum total bile acid (sTBA) among all groups ( < 0.05). The NLR in the severe ICP group was significantly higher than that in the mild ICP group ( < 0.05). Logistic regression analysis showed that MPV (odds ratio [OR] = 1.247) and NLR (OR = 1.885) were independent factors influencing the occurrence of ICP ( < 0.05). ROC curve analysis showed that the area under the curve (AUC) for both mild ICP and severe ICP was 0.679 and 0.869, respectively, substantiating the diagnostic value of NLR. NLR can be used as an auxiliary indicator in the diagnosis of ICP and has important clinical value in predicting adverse pregnancy outcomes in ICP patients.
妊娠期肝内胆汁淤积症（ICP）与不良围产期结局相关，但ICP与中性粒细胞与淋巴细胞比值（NLR）之间的相关性仍不清楚。本研究旨在探讨NLR在ICP中的诊断价值。在这项回顾性病例对照研究中，招募了2020年1月至2022年12月在北仑区人民医院接受治疗的113例ICP患者，并将其归类为ICP组，同时选择同期治疗的209例健康孕妇作为对照组。比较两组的NLR和平均血小板体积（MPV）水平。比较不同ICP严重程度患者的NLR。采用Logistic回归模型分析相关指标与ICP的关系。使用受试者工作特征（ROC）曲线评估NLR预测ICP的能力。所有组之间在年龄、中性粒细胞计数、淋巴细胞计数、血小板计数、MPV、碱性磷酸酶（ALP）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、NLR和血清总胆汁酸（sTBA）方面存在显著差异（<0.05）。重度ICP组的NLR显著高于轻度ICP组（<0.05）。Logistic回归分析显示，MPV（比值比[OR]=1.247）和NLR（OR=1.885）是影响ICP发生的独立因素（<0.05）。ROC曲线分析显示，轻度ICP和重度ICP的曲线下面积（AUC）分别为0.679和0.869，证实了NLR的诊断价值。NLR可作为ICP诊断的辅助指标，对预测ICP患者的不良妊娠结局具有重要临床价值。
