Cox S R, Harrington E L, Hill R A, Capponi V J, Shah A C
Biopharm Drug Dispos. 1985 Jan-Mar;6(1):67-80. doi: 10.1002/bdd.2510060109.
Three separate Latin square crossover studies were conducted in beagles to examine the effect of a meal on the bioavailability of a ciglitazone tablet, suspension, and solution. In these studies, drug was administered to fasted animals with either 50 ml water or with 180 g Purina Dog Chow and 20 g butter. The data indicated that the meal significantly increased the AUC by about 40 per cent for both the tablet and the suspension but had no significant effect on the solution treatment. Comparisons across studies indicated low bioavailability in fasted animals from either the tablet or suspension relative to the solution. When drug was co-administered with a meal, however, bioavailability appeared to be independent of dosage form.
在比格犬身上进行了三项独立的拉丁方交叉研究，以考察进餐对环格列酮片、混悬剂和溶液生物利用度的影响。在这些研究中，给禁食动物服用药物，同时给予50毫升水或180克普瑞纳狗粮和20克黄油。数据表明，进餐使片剂和混悬剂的AUC显著增加约40%，但对溶液制剂没有显著影响。各项研究之间的比较表明，相对于溶液制剂，禁食动物服用片剂或混悬剂后的生物利用度较低。然而，当药物与进餐同时服用时，生物利用度似乎与剂型无关。
