Xing Tian, Wang Jiawei, Wei Jiaqing, Du Xingxing, Hong Ruijin, Tao Chunxian, Wang Qi, Lin Hui, Han Zhaoxia, Zhang Dawei
Engineering Research Center of Optical Instrument and System, Ministry of Education and Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, No.516 Jungong Road, Shanghai, 200093, China.
Engineering Research Center of Optical Instrument and System, Ministry of Education and Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, No.516 Jungong Road, Shanghai, 200093, China.
Anal Chim Acta. 2025 Feb 22;1340:343666. doi: 10.1016/j.aca.2025.343666. Epub 2025 Jan 13.
Surface-enhanced Raman scattering (SERS) has attracted much attention as a powerful detection and analysis tool with high sensitivity and fast detection speed. The intensity of the SERS signal mainly depended on the highly enhanced electromagnetic field of nanostructure near the substrate. However, the fabrication of high-quality SERS nanostructured substrates is usually complicated, makes many methods unsuitable for large-scale production of SERS substrates. A new strategic preparation method is needed, which is simple and inexpensive in the preparation process, can achieve large-scale mass production, and also ensures the good performance of the SERS substrate.
For the first time, we propose constructing a silver (Ag) surface-enhanced Raman scattering (SERS) substrate with different angular quadrilateral periodic arrays by combining a mask plate and vapor deposition. The mask plate can precisely control the period and angle of the nano-arrays, and thus regulate the intensity of the local "hot spots". The analytical results show that the tetragonal periodic Ag SERS substrate with a 15° angle of the mask plate exhibits a significant enhancement effect in the detection of Rhodamine 6G (R6G), Rhodamine B (RhB), and Methyl Orange (MO) probe molecules, and the limit of detection (LOD) of this substrate is low as 10 mol/L for all the three solutions. The enhancement factors (EFs) are 6.5 × 10, 4.2 × 10, and 2.6 × 10, respectively. The accuracy of the experimental results was further verified through a finite-difference time-domain (FDTD) simulation.
In this paper, we propose that the SERS substrate was fabricated using the new strategy with a lower detection limit for multiple dye molecules simultaneously. The results show that the SERS substrate prepared in this study has great potential for applications in high-performance SERS sensors. Additionally, this new preparation method may also be applicable to other metal materials, offering broad research prospects.
表面增强拉曼散射（SERS）作为一种具有高灵敏度和快速检测速度的强大检测与分析工具，已引起广泛关注。SERS信号强度主要取决于基底附近纳米结构高度增强的电磁场。然而，高质量SERS纳米结构基底的制备通常较为复杂，导致许多方法不适用于SERS基底的大规模生产。因此需要一种新的策略制备方法，该方法在制备过程中简单且成本低廉，能够实现大规模批量生产，同时确保SERS基底具有良好性能。
我们首次提出通过结合掩膜板和气相沉积构建具有不同角度四边形周期阵列的银（Ag）表面增强拉曼散射（SERS）基底。掩膜板可精确控制纳米阵列的周期和角度，从而调节局部“热点”的强度。分析结果表明，掩膜板角度为15°的四方周期Ag SERS基底在检测罗丹明6G（R6G）、罗丹明B（RhB）和甲基橙（MO）探针分子时表现出显著的增强效果，该基底对所有三种溶液的检测限低至10⁻⁹ mol/L。增强因子（EFs）分别为6.5×10⁵、4.2×10⁵和2.6×10⁵。通过时域有限差分（FDTD）模拟进一步验证了实验结果的准确性。
本文提出采用新策略制备的SERS基底对多种染料分子同时具有较低检测限。结果表明，本研究制备的SERS基底在高性能SERS传感器应用中具有巨大潜力。此外，这种新的制备方法也可能适用于其他金属材料，具有广阔的研究前景。
