Kasymov A Kh, Kasymov Sh Z, Vorozheĭkin V M, Kirichenko I P
Biull Eksp Biol Med. 1985 Mar;99(3):368-70.
Extracorporeal perfusion of toxic blood via carbonic sorbents is an effective method for correcting severe disturbances of hemostasis. Ultrastructural alterations in hepatic cells were studied in experimental toxic liver injury before and after hemosorption. It was established that after hemosorption the processes of intracellular regeneration were significantly activated in the liver parenchyma. The number of crysts in the mitochondria increased as did the electronic density of the matrix. At the same time the number of lysosomes rose as well. However, in persistent unresolved cholestasis, destructive alterations in the hepatic tissue progressed despite the performance of hemosorption.
通过碳酸吸附剂对中毒血液进行体外灌注是纠正严重止血障碍的有效方法。在实验性中毒性肝损伤的血液吸附前后，对肝细胞的超微结构变化进行了研究。结果表明，血液吸附后肝实质内的细胞内再生过程明显激活。线粒体中的嵴数量增加，基质的电子密度也增加。同时，溶酶体的数量也增加。然而，在持续性未解决的胆汁淤积中，尽管进行了血液吸附，肝组织的破坏性变化仍在进展。
