Guo Y L, Zhang D Y, Xu S J, Zhang M J, Li J
Department of General Medicine the First Affiliated Hospital of Soochow University, Suzhou215006,China.
Health Management Center the First Affiliated Hospital of Soochow University, Suzhou215006,China.
Zhonghua Nei Ke Za Zhi. 2025 Feb 1;64(2):128-133. doi: 10.3760/cma.j.cn112138-20240812-00506.
To analyze the occurrence of metabolic dysfunction-associated fatty liver disease (MAFLD) and related inflammatory indicators in obstructive sleep apnea hypopnea syndrome (OSAHS) and explore the risk factors of MAFLD. A cross-sectional study. From January 2022 to October 2024,172 patients with sleep disorders were enrolled in the First Affiliated Hospital of Soochow University,including 38 patients with non-OSAHS,53 patients with mild OSAHS,37 patients with moderate OSAHS,and 44 patients with severe OSAHS. The occurrence of MAFLD was comprehensively judged from three aspects: metabolic dysfunction-associated fatty liver (MAFL),elevated liver enzymes,and liver fibrosis. The situation of MAFLD and the level of related inflammatory markers were compared among the four groups. Binary logistic regression was used to analyze the risk factors for MAFLD in OSAHS. There were significant differences in the prevalence of MAFL,the percentage of elevated liver enzymes,and interleukin-6 and tumor necrosis factor-alpha levels among the four groups (<0.05). The differences of fibrosis-4 index and C-reactive protein among the four groups were not statistically significant (>0.05). Binary logistic regression showed that BMI,triglycerides,longest time of sleep apnea and tumor necrosis factor-alpha were the risk factors for MAFL (<0.05). BMI,glucose,and apnea-hypopnea index were the risk factors for elevated liver enzymes (<0.05). OSAHS is strongly associated with MAFLD,and the involvement of OSAHS in the occurrence and development of MAFLD may be related to obesity,lipid metabolism disorders,insulin resistance,inflammatory responses,and intermittent hypoxia.
分析阻塞性睡眠呼吸暂停低通气综合征（OSAHS）中代谢功能障碍相关脂肪性肝病（MAFLD）的发生情况及相关炎症指标，探讨MAFLD的危险因素。一项横断面研究。2022年1月至2024年10月，苏州大学附属第一医院纳入172例睡眠障碍患者，其中非OSAHS患者38例，轻度OSAHS患者53例，中度OSAHS患者37例，重度OSAHS患者44例。从代谢功能障碍相关脂肪性肝病（MAFL）、肝酶升高和肝纤维化三个方面综合判断MAFLD的发生情况。比较四组中MAFLD的情况及相关炎症标志物水平。采用二元logistic回归分析OSAHS中MAFLD的危险因素。四组间MAFL患病率、肝酶升高百分比、白细胞介素-6和肿瘤坏死因子-α水平存在显著差异（<0.05）。四组间纤维化-4指数和C反应蛋白差异无统计学意义（>0.05）。二元logistic回归显示，BMI、甘油三酯、最长呼吸暂停时间和肿瘤坏死因子-α是MAFL的危险因素（<0.05）。BMI、血糖和呼吸暂停低通气指数是肝酶升高的危险因素（<0.05）。OSAHS与MAFLD密切相关，OSAHS参与MAFLD的发生发展可能与肥胖、脂质代谢紊乱、胰岛素抵抗、炎症反应和间歇性缺氧有关。
