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[肺炎支原体与流感病毒混合感染的叙利亚仓鼠肺部肿瘤的发生]

[Development of lung tumors in Syrian hamsters with a mixed Mycoplasma pneumoniae and influenza virus infection].

作者信息

Bezuglova T V, Lange A, Gusman B S, Ritter E

出版信息

Biull Eksp Biol Med. 1985 Apr;99(4):476-7.

PMID:3986374
Abstract

The authors studied morphological alterations in the lungs of Syrian hamsters infected intranasally with Mycoplasma pneumoniae and influenza virus. The animals were first infected with M. pneumoniae and after 7 days with influenza A/PR8 virus. On days 1-3 after infection with influenza virus (days 8-11 following infection with M. pneumoniae) the animals showed the appearance of multiple foci of bronchiolar epithelium proliferation. At the later stages of experiment the size of the foci of proliferation increased. On days 14-21 after infection with influenza virus (days 21-28 of experiment) the animals developed lung tumors.

摘要

作者研究了经鼻感染肺炎支原体和流感病毒的叙利亚仓鼠肺部的形态学改变。动物首先感染肺炎支原体,7天后再感染甲型流感病毒A/PR8。在感染流感病毒后的第1 - 3天(感染肺炎支原体后的第8 - 11天),动物出现细支气管上皮细胞增殖的多个病灶。在实验后期,增殖病灶的大小增加。在感染流感病毒后的第14 - 21天(实验的第21 - 28天),动物发生了肺部肿瘤。

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