Nakajima Yoichiro, Kato-Kogoe Nahoko, Yasuda Takako, Urakawa Rika, Matsuo Tomoka, Omori Michi, Ueno Takaaki, Takeuchi Tohru
Department of Dentistry and Oral Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Research and Development Department, Sunstar Inc., Takatsuki, Osaka, Japan.
Med Sci Monit. 2025 Jan 26;31:e947146. doi: 10.12659/MSM.947146.
BACKGROUND Periodontal disease and rheumatoid arthritis (RA) are closely related, and periodontal therapy can potentially improve RA activity. However, it is not clear in which RA patient populations are more effective periodontal therapy for RA treatment. This study aimed to evaluate the effects of treatment for periodontal disease in 30 patients with rheumatoid arthritis and the titers of antibodies to Porphyromonas gingivalis (P. gingivalis). MATERIAL AND METHODS Thirty patients with RA with mild to severe periodontitis were divided into 3 groups based on the timing of periodontal therapy initiation. RA activity was assessed at baseline and at 3, 6, 9, and 12 months for comparison across groups. Additionally, serum P. gingivalis antibody titers were measured at baseline, patients were divided into 3 groups based on their levels, and their RA activity was compared after 12 months. RESULTS Patients who started periodontal therapy concurrently with RA treatment initiation at baseline showed greater improvement in RA activity, measured by disease activity score, including 28 joints using C-reactive protein (DAS28-CRP), from baseline to 3 months than those who started periodontal therapy after RA treatment. Additionally, RA activity by DAS28-CRP after 12 months of RA treatment with periodontal therapy was significantly improved in patients with higher baseline serum IgG antibody titers against P. gingivalis than in those with lower titers. CONCLUSIONS Treatment for periodontal disease in patients with RA is more effective in patients with early-phase RA and higher serum P. gingivalis antibody titers.
牙周疾病与类风湿关节炎（RA）密切相关，牙周治疗可能改善RA的病情活动。然而，尚不清楚牙周治疗对哪些RA患者群体治疗RA更有效。本研究旨在评估30例类风湿关节炎患者的牙周疾病治疗效果及牙龈卟啉单胞菌（牙龈卟啉单胞菌）抗体滴度。材料与方法：30例轻至重度牙周炎的RA患者根据牙周治疗开始时间分为3组。在基线以及3、6、9和12个月时评估RA病情活动，以进行组间比较。此外，在基线时测量血清牙龈卟啉单胞菌抗体滴度，根据抗体水平将患者分为3组，并在12个月后比较他们的RA病情活动。结果：与在RA治疗后开始牙周治疗的患者相比，在基线时与RA治疗开始同时启动牙周治疗的患者，通过疾病活动评分（包括使用C反应蛋白的28个关节的疾病活动评分（DAS28-CRP））测量，从基线到3个月RA病情活动改善更大。此外，在接受牙周治疗的RA治疗12个月后，基线血清抗牙龈卟啉单胞菌IgG抗体滴度较高的患者的DAS28-CRP所反映的RA病情活动比滴度较低的患者有显著改善。结论：RA患者的牙周疾病治疗在早期RA患者和血清牙龈卟啉单胞菌抗体滴度较高的患者中更有效。
