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下牙槽神经感觉障碍药物治疗的新趋势:一项范围综述

Emerging trends in pharmacological treatment of inferior alveolar nerve sensory disorders: a scoping review.

作者信息

Mesquita B-D, Gomes A-C, Vasconcelos B-C, Lago C-A, Arruda M-R, Andrade E-S

机构信息

Department of Oral and Maxillofacial Surgery and Traumatology University of Pernambuco. Av. Gov. Agamenon Magalhães Santo Amaro, Recife - PE, CEP 50100-010, Brazil

出版信息

Med Oral Patol Oral Cir Bucal. 2025 Mar 1;30(2):e170-e178. doi: 10.4317/medoral.26519.

Abstract

BACKGROUND

Sensory disorders of the inferior alveolar nerve, often arising from dental procedures, markedly impact the quality of life of patients. This article proposes a scoping review to analyze emerging trends in pharmacological treatment for these disorders, addressing scientific gaps and clinical practices.

MATERIAL AND METHODS

The review followed the PRISMA-ScR protocol, conducting data searches across various databases, including PubMed and Cochrane, until March 2024. Case studies and series related to patients with sensory disorders of the inferior alveolar nerve undergoing pharmacological treatment were included.Parte inferior do formulário Results: Out of the initial 542 records, 7 studies were included after rigorous selection, displaying low bias risk. Medicinal therapies varied, encompassing analgesics, corticosteroids, anesthetics, and vitamin complexes. Dipyrone stood out in the preoperative phase, while prednisone proved effective in paresthesias. Selegiline, an MAO-B inhibitor, introduced an innovative approach.

CONCLUSIONS

Agents such as selegiline offer an innovative approach to sensory restoration, while corticosteroids exhibit variable efficacy. Dipyrone is effective in preoperative pain control, and vitamin complexes provide regenerative and neuroprotective benefits. However, it is essential to consider that treatment success may vary and to address the individual needs of patients.

摘要

背景

下牙槽神经感觉障碍常由牙科手术引起,严重影响患者的生活质量。本文提出一项范围综述,以分析这些疾病药物治疗的新趋势,填补科学空白并规范临床实践。

材料与方法

该综述遵循PRISMA-ScR方案,在包括PubMed和Cochrane在内的多个数据库中进行数据检索,直至2024年3月。纳入了接受药物治疗的下牙槽神经感觉障碍患者的病例研究和系列报道。

结果

在最初的542条记录中,经过严格筛选后纳入了7项研究,显示出较低的偏倚风险。药物治疗方法多样,包括镇痛药、皮质类固醇、麻醉药和维生素复合物。安乃近在术前阶段表现突出,而泼尼松在感觉异常方面被证明有效。单胺氧化酶B抑制剂司来吉兰引入了一种创新方法。

结论

司来吉兰等药物为感觉恢复提供了创新方法,而皮质类固醇的疗效各不相同。安乃近在术前疼痛控制方面有效,维生素复合物具有再生和神经保护作用。然而,必须考虑到治疗结果可能因人而异,并满足患者的个体需求。

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