Zincke H, Patterson D E, Utz D C, Benson R C
Br J Urol. 1985 Apr;57(2):156-9. doi: 10.1111/j.1464-410x.1985.tb06411.x.
Past and present methods of treatment for patients with stage D1 (T1-4 N+ MO) transitional cell cancer of the urinary bladder have proved to be largely ineffective. This report on 57 patients with stage D1 disease confirms this impression and demonstrates that radical operation alone is associated with a 5-year survival rate of only 10%. Survival is related to tumour grade and to the number of pelvic lymph nodes involved; furthermore, complete lymphadenectomy may contribute to improved patient survival. Effective treatment programmes for stage D1 bladder cancer are lacking and efforts should be directed toward developing treatment protocols that combine radical cystectomy and meticulous pelvic node dissection with an effective adjuvant systemic treatment programme.
过去和现在用于治疗D1期（T1 - 4 N + M0）膀胱移行细胞癌患者的方法已被证明在很大程度上是无效的。这份关于57例D1期疾病患者的报告证实了这一观点，并表明仅进行根治性手术的5年生存率仅为10%。生存率与肿瘤分级以及盆腔淋巴结受累数量有关；此外，完整的淋巴结清扫术可能有助于提高患者生存率。目前缺乏针对D1期膀胱癌的有效治疗方案，应致力于制定将根治性膀胱切除术、细致的盆腔淋巴结清扫术与有效的辅助全身治疗方案相结合的治疗方案。
