Borkhataria Chetan H, Sharma Shweta, Vaja Payal, Tank Chintankumar, Mori Dhaval, Patel Kalpesh, Kyada Ashishkumar
B K Mody Government Pharmacy College Rajkot Gujarat India.
B K Mody Government Pharmacy College Rajkot Gujarat India.
Clin Chim Acta. 2025 Mar 1;569:120161. doi: 10.1016/j.cca.2025.120161. Epub 2025 Jan 24.
The integration of genomics into personalized medicine has the potential to transform healthcare by customizing treatments according to individual genetic profiles. This paper examines the diverse applications of genomics, including the identification of disease susceptibility, improvement of diagnostic methods, optimization of drug therapies, and monitoring of treatment responses. It also explores the expanding global market for genetic testing and the increasing implementation of whole-genome sequencing in clinical practice, with a focus on pilot programs that are advancing comprehensive genomic analysis. Despite challenges such as high costs, data interpretation complexities, and ethical concerns, significant efforts are being made to address these issues. Additionally, the creation of biobanks as vital resources for preserving high-quality biosamples and supporting research highlights the critical need for infrastructure development in genomics. By fostering interdisciplinary collaboration and establishing robust ethical and regulatory frameworks, personalized medicine can ensure equitable access to tailored therapies and enhance health outcomes for everyone. This abstract provides an overview of the transformative potential of genomics and personalized medicine in ushering in a new era of precision healthcare.
将基因组学整合到个性化医疗中，有潜力通过根据个体基因图谱定制治疗方案来变革医疗保健。本文探讨了基因组学的多种应用，包括疾病易感性的识别、诊断方法的改进、药物治疗的优化以及治疗反应的监测。它还探讨了不断扩大的全球基因检测市场以及全基因组测序在临床实践中日益增加的应用，重点关注推进全面基因组分析的试点项目。尽管存在高成本、数据解读复杂以及伦理问题等挑战，但人们正在做出重大努力来解决这些问题。此外，建立生物样本库作为保存高质量生物样本和支持研究的重要资源，凸显了基因组学基础设施发展的迫切需求。通过促进跨学科合作并建立强有力的伦理和监管框架，个性化医疗可以确保公平获得量身定制的疗法，并改善每个人的健康状况。本摘要概述了基因组学和个性化医疗在开创精准医疗新时代方面的变革潜力。
