Esquivel Samir, Zuñiga Martina, Meléndrez Manuel, Pereira Eduardo, Urbano Bruno F, Rivas Bernabé L, Palacio Daniel A
Polymers Department, Faculty of Chemical Sciences, University of Concepción, Box 160-C, Concepción 4070371, Chile.
Faculty of Healthcare Sciences, San Sebastián University, Las Tres Pascualas Campus, Lientur 1457, Concepción 4060000, Chile.
Int J Biol Macromol. 2025 Apr;300:140303. doi: 10.1016/j.ijbiomac.2025.140303. Epub 2025 Jan 24.
The contamination of water systems by antibiotics such as ciprofloxacin (CIP), which is used to treat bacterial infections, poses severe risks to environmental safety and public health. To address this issue, a novel zwitterionic polymeric nanocomposite (PNs-HTC) was developed in this study. This novel material was synthesized using alkylated chitosan ionic macromonomers, ionic monomers and combined with hydrotalcite (HTC) via in situ free radical polymerization. The incorporation of quaternary ammonium and vinyl groups into the chitosan backbone, along with varying HTC contents, considerably impacted the properties of the nanocomposite. The nanocomposite was characterized using Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, X-ray diffraction, and thermogravimetric analysis. The effectiveness of PNs-HTC in removing CIP from water was evaluated under different conditions. PNs-HTC exhibited a CIP adsorption capacity of up to 84.43 mg g at 318 K. Equilibrium data fitted well to the Temkin isotherm and pseudo-second-order kinetic models. The pH, ionic strength (30 % using 0.1 M NaCl), and HTC content in the nanocomposite influenced CIP adsorption, which reached a maximum of 80 % using 0.03 g of PNs-HTC. Thermodynamic studies indicated that the adsorption process was favorable, spontaneous, and endothermic and was marked by significant randomness. These findings underscore the potential of PNs-HTC as a robust material for mitigating antibiotic pollution in aquatic environments.
用于治疗细菌感染的抗生素如环丙沙星（CIP）对水系统的污染，对环境安全和公众健康构成了严重风险。为了解决这一问题，本研究开发了一种新型两性离子聚合物纳米复合材料（PNs-HTC）。这种新型材料是使用烷基化壳聚糖离子大分子单体、离子单体合成，并通过原位自由基聚合与水滑石（HTC）复合而成。壳聚糖主链中季铵基和乙烯基的引入以及不同的HTC含量，对纳米复合材料的性能有很大影响。使用傅里叶变换红外光谱、核磁共振光谱、X射线衍射和热重分析对该纳米复合材料进行了表征。在不同条件下评估了PNs-HTC从水中去除CIP的效果。PNs-HTC在318K时对CIP的吸附容量高达84.43mg/g。平衡数据与Temkin等温线和准二级动力学模型拟合良好。pH值、离子强度（使用0.1M NaCl时为30%）以及纳米复合材料中的HTC含量会影响CIP的吸附，使用0.03g PNs-HTC时吸附率最高可达80%。热力学研究表明，吸附过程是有利的、自发的且吸热的，具有显著的随机性。这些发现强调了PNs-HTC作为减轻水生环境中抗生素污染的一种强大材料的潜力。
