Zhang Yanyan, Zhong Yan, Mao Wei, Zhang Zhe, Zhou Yusheng, Li Hu, Ying Jianing, Yi Quanyong
Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, Zhejiang 315000, PR China.
The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315000, PR China.
Photodiagnosis Photodyn Ther. 2025 Apr;52:104493. doi: 10.1016/j.pdpdt.2025.104493. Epub 2025 Jan 27.
To evaluate the differences in fundus tessellation among various severities using multifocal visual electrophysiology (MfERG) and optical coherence tomography angiography (OCTA) for clinical grading and treatment.
This study included 52 patients totaling 87 eyes. The Early Treatment Diabetic Retinopathy Study (ETDRS) grid division method was utilized to assess Grade of fundus tessellation. Data obtained via OCTA and ImageJ software included macular foveal thickness (MT), subfoveal choroidal thickness (SFCT), superficial retinal capillary layer vascular density (SVD), deep retinal capillary layer vascular density (DVD), and choroidal blood capillary layer blood flow density (CFD). Multifocal visual electrophysiology equipment provided latency and amplitude of N1 and P1 waves. Differences and changes among the four Grade of fundus tessellation grading were compared, and ROC curve analysis was performed to identify the optimal choroidal thickness indicators for predicting the grading of fundus tessellation.
SFCT tends to decrease as the grade of fundus tessellation increases. and the amplitudes of N1 and P1 waves in multifocal electroretinography reduce, with an elongation in their latency periods. Correlation analysis showed that SFCT positively correlated with N1 and P1 amplitudes (r = 0.270, 0.246; P < 0.05) and negatively correlated with their latency periods (r=-0.219, -0.248; P < 0.05). The ROC curve results indicated the cutoff values for SFCT were 192.75 µm between Grade 1 and 2, 162 µm between Grade 2 and 3, and 130.75 µm between Grade 3 and 4.
Assessment in fundus tessellation using MfERG and OCTA contributes to objective grading of fundus tessellation and further help to clinical prediction and treatment.
Assessment in fundus tessellation morphologically and functionally using MfERG and OCTA contributes to classification and clinical prediction of fundus tessellation.
利用多焦视觉电生理（MfERG）和光学相干断层扫描血管造影（OCTA）评估不同严重程度的眼底镶嵌的差异，以用于临床分级和治疗。
本研究纳入52例患者共87只眼。采用糖尿病视网膜病变早期治疗研究（ETDRS）网格划分法评估眼底镶嵌等级。通过OCTA和ImageJ软件获得的数据包括黄斑中心凹厚度（MT）、中心凹下脉络膜厚度（SFCT）、视网膜浅层毛细血管层血管密度（SVD）、视网膜深层毛细血管层血管密度（DVD）以及脉络膜毛细血管层血流密度（CFD）。多焦视觉电生理设备提供N1和P1波的潜伏期和振幅。比较眼底镶嵌等级四级之间的差异和变化，并进行ROC曲线分析以确定预测眼底镶嵌分级的最佳脉络膜厚度指标。
随着眼底镶嵌等级增加，SFCT有降低趋势，多焦视网膜电图中N1和P1波的振幅降低，潜伏期延长。相关性分析显示，SFCT与N1和P1波振幅呈正相关（r = 0.270，0.246；P < 0.05），与潜伏期呈负相关（r = -0.219，-0.248；P < 0.05）。ROC曲线结果表明，SFCT在1级和2级之间的截断值为192.75 µm，2级和3级之间为162 µm，3级和4级之间为130.75 µm。
使用MfERG和OCTA评估眼底镶嵌有助于眼底镶嵌的客观分级，并进一步辅助临床预测和治疗。
使用MfERG和OCTA从形态和功能上评估眼底镶嵌有助于眼底镶嵌的分类和临床预测。
