Chen Sida, Hou Jian, Huang Yang, Pan Jinyu, Liu Kaizheng, Chen Guangxian, Wu Zhongkai, Wu Haoyi
Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, GD, China.
School of Physics and Optoelectronic Engineering, Guangdong University of Technology, HEMC, Guangzhou, China.
Heliyon. 2025 Jan 3;11(1):e41701. doi: 10.1016/j.heliyon.2025.e41701. eCollection 2025 Jan 15.
The AlO: Cr light-converting materials were successfully synthesized via co-precipitation, resulting in a grain size ranging from 100 to 400 nm. Under excitation wavelengths spanning from 360 to 650 nm, a distinct near-infrared (NIR) emission at 695 nm was observed. Through optimization, it has been established that a Cr doping concentration of 1.0 mol% results from the optimal emission intensity. The material shows relatively stable in water and it was employed to cultivate the H9C2 cells, and the NIR emission from the cells was observed, indicating the successful absorption of the material by the cells. Additionally, the toxicity of the material was examined, by reducing the concentration to 2 nM/mL, the toxicity of the material was significantly reduced to a promising level. Therefore, the suitable grain size, NIR emission and the biocompatibility renders this material a candidate in cell imaging.
通过共沉淀法成功合成了AlO:Cr光转换材料，其晶粒尺寸在100至400纳米之间。在360至650纳米的激发波长下，观察到在695纳米处有明显的近红外（NIR）发射。通过优化，已确定Cr掺杂浓度为1.0摩尔%时发射强度最佳。该材料在水中表现出相对稳定性，并用于培养H9C2细胞，观察到细胞发出的近红外发射，表明该材料已被细胞成功吸收。此外，还检测了该材料的毒性，将浓度降低到2 nM/mL时，材料的毒性显著降低到一个有前景的水平。因此，合适的晶粒尺寸、近红外发射和生物相容性使这种材料成为细胞成像的候选材料。
