Schaller Megan L, Sykes Madeline M, Easow Sarah A, Carranza Faith R, Tuckowski Angela M, Shah Yatrik M, Leiser Scott F
Molecular and Integrative Physiology Department, University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States.
Department of Molecular and Cellular Pathology, University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States.
MicroPubl Biol. 2025 Jan 10;2025. doi: 10.17912/micropub.biology.001422. eCollection 2025.
pathogenic susceptibility is influenced by the worm's detection of its environment and its capacity to resist and resolve damage following infection. Here, we use a model where worms can sense, but not ingest, the pathogen (EF) We identify that perception of EF without infection induces the stress-response gene further identify that neural and intestinal signaling genes are necessary for induction without active infection. Finally, we show that overexpression is sufficient to extend lifespan with EF exposure, while KO is not detrimental, suggesting that additional expression benefits worms in this condition.
致病易感性受蠕虫对其环境的检测以及感染后抵抗和解决损伤的能力影响。在此，我们使用一种模型，其中蠕虫能够感知但不摄取病原体（EF）。我们发现未感染时对EF的感知会诱导应激反应基因，进一步发现神经和肠道信号基因对于无主动感染时的诱导是必需的。最后，我们表明过表达足以在暴露于EF的情况下延长寿命，而敲除则无害，这表明额外的[基因名称]表达在这种情况下对蠕虫有益。 （注：原文中“the stress-response gene”以及“ KO”“ overexpression”等部分内容不完整，翻译时根据语境进行了适当补充以使译文逻辑相对完整，但严格按照要求保留了原文的不完整性表述。）
