Tas Emre Erdem, Ozgen Eyup, Yilmaz Gamze, Senat Almila
Emre Erdem Tas, Department of Obstetrics and Gynecology, Republic of Turkey Ministry of Health, Ankara City Hospital, Turkey.
Eyup Ozgen, Department of Obstetrics and Gynecology, Guven Hospital, Ankara, Turkey.
Pak J Med Sci. 2025 Jan;41(1):130-135. doi: 10.12669/pjms.41.1.10170.
This study aimed to investigate the relationship between oxidative stress (OS) and endometrial polyps (EP) in pre- versus postmenopausal women with abnormal uterine bleeding.
This prospective case control study was conducted in the Gynecology Department of Ankara Bilkent City Hospital between January and December 2019. In this study, the EP and control groups included 45 participants each (30 pre- and 15 postmenopausal women). Demographics (age, gravidity, parity, and body mass index), serum complete blood count parameters, serum total antioxidant status, total oxidant status (TOS), oxidative stress index (OSI), and thiol/disulfide balance were compared between groups. Subsequently, all women were stratified based on menopausal status, and the investigated parameters were investigated separately in the pre- and postmenopausal participants between groups.
There were no significant intergroup differences in the investigated parameters among all participants (P>0.05). However, unlike in the control group, the age distribution in the EP group was bimodal, peaking in the early 40s and late 50s. Stratification based on menopausal status revealed no significant intergroup differences in the investigated parameters among the premenopausal participants. However, among the postmenopausal participants, serum TOS and OSI levels were significantly higher in the EP versus control group (9.0 vs. 7.2 μmol HO Equiv/L and 0.8 vs. 0.6 AU; P=0.01).
Serum OS may play a role in the development of EP, particularly among postmenopausal women. Further investigations are required in this area.
本研究旨在调查绝经前后子宫异常出血女性中氧化应激（OS）与子宫内膜息肉（EP）之间的关系。
本前瞻性病例对照研究于2019年1月至12月在安卡拉比尔肯特市医院妇科进行。在本研究中，EP组和对照组各包括45名参与者（30名绝经前和15名绝经后女性）。比较两组之间的人口统计学特征（年龄、妊娠次数、产次和体重指数）、血清全血细胞计数参数、血清总抗氧化状态、总氧化状态（TOS）、氧化应激指数（OSI）和硫醇/二硫键平衡。随后，所有女性根据绝经状态进行分层，所研究的参数在绝经前和绝经后参与者组间分别进行研究。
所有参与者中，所研究参数在组间无显著差异（P>0.05）。然而，与对照组不同，EP组的年龄分布呈双峰型，在40岁出头和50岁后期达到峰值。根据绝经状态分层显示，绝经前参与者中所研究参数在组间无显著差异。然而，在绝经后参与者中，EP组的血清TOS和OSI水平显著高于对照组（分别为9.0对7.2 μmol HO Equiv/L和0.8对0.6 AU；P=0.01）。
血清OS可能在EP的发生中起作用，尤其是在绝经后女性中。该领域需要进一步研究。
