Tay Elena, Loo Wei Jing
Western University, London, ON, Canada.
DermEffects, London, ON, Canada.
Clin Cosmet Investig Dermatol. 2025 Jan 20;18:161-167. doi: 10.2147/CCID.S498879. eCollection 2025.
Acne vulgaris is a globally prevalent dermatological condition associated with substantial physical and psychological burden. Although acne typically presents during adolescence, it is a chronic condition that also affects many adults. Despite the spectrum of treatments available for acne, limitations in tolerability and safety concerns can present challenges for the use of conventional medications in clinical practice. Clascoterone cream 1%, a topical androgen receptor inhibitor, was recently approved in Canada for the topical treatment of acne vulgaris. This case series included 10 patients with acne vulgaris who were treated with clascoterone cream 1% as monotherapy or part of a combination treatment program between August 2023 and May 2024. Clascoterone cream 1% was effective and well tolerated regardless of acne severity, age, gender, and ethnicity. Clascoterone led to clinical improvement when used as monotherapy, adjunctive treatment in combination with other topical or systemic agents or laser therapy, and as maintenance therapy to prevent relapse of acne. Moreover, clascoterone also helped to address other concerns in several patients, including hirsutism, hidradenitis suppurativa, retinoid-induced dermatitis, androgenetic alopecia, folliculitis, postinflammatory hyperpigmentation, and laser-induced acne flares. This early real-world clinical experience supports the effectiveness, tolerability, and versatility of clascoterone cream 1% for patients with acne across a variety of clinical and demographic characteristics.
寻常痤疮是一种全球流行的皮肤病，会带来相当大的身心负担。虽然痤疮通常在青春期出现，但它是一种慢性疾病，也会影响许多成年人。尽管有多种治疗痤疮的方法，但耐受性方面的局限性和安全问题可能给临床实践中使用传统药物带来挑战。1%的氯睾酮乳膏是一种局部雄激素受体抑制剂，最近在加拿大被批准用于局部治疗寻常痤疮。该病例系列包括10例寻常痤疮患者，他们在2023年8月至2024年5月期间接受了1%氯睾酮乳膏单一疗法或联合治疗方案的一部分治疗。无论痤疮严重程度、年龄、性别和种族如何，1%氯睾酮乳膏都有效且耐受性良好。氯睾酮作为单一疗法、与其他局部或全身药物或激光治疗联合使用的辅助治疗以及作为预防痤疮复发的维持治疗时，都能带来临床改善。此外，氯睾酮还帮助解决了几名患者的其他问题，包括多毛症、化脓性汗腺炎、维甲酸引起的皮炎、雄激素性脱发、毛囊炎、炎症后色素沉着以及激光诱发的痤疮发作。这种早期的真实世界临床经验支持了1%氯睾酮乳膏对具有各种临床和人口统计学特征的痤疮患者的有效性、耐受性和多功能性。
