儿童IgE介导的食物过敏治疗的新方法。
New approaches in childhood IgE-mediated food allergy treatment.
作者信息
Gurel Deniz Ilgun, Anagnostou Aikaterini, Fiocchi Alessandro, Sharon Chinthrajah, Sahiner Umit, Sindher Sayantani, Arasi Stefania
机构信息
Translational Research in Pediatric Specialities, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Hacettepe University Ihsan Dogramaci Children's Hospital, Division of Pediatric Allergy and Immunology, Ankara, Turkey.
出版信息
Curr Opin Allergy Clin Immunol. 2025 Apr 1;25(2):115-122. doi: 10.1097/ACI.0000000000001058. Epub 2025 Jan 27.
PURPOSE OF REVIEW
This review aims to provide an overview of the current and future treatment options for children with food allergies (FAs), highlighting the latest research findings and the potential impact of these new approaches on improving patients' and caregivers' quality of life.
RECENT FINDINGS
In the last decade, many promising approaches have emerged as an alternative to the standard avoidance of the culprit food with the risk of severe accidental reactions. Desensitization through oral immunotherapy has been introduced in clinical settings as a therapeutic approach, and more recently also omalizumab. In addition, alternative routes of administration for immunotherapy, other biologics, small molecules, probiotics or prebiotics, microbiota transplantation therapy, IGNX001, and PVX108 are being investigated.
SUMMARY
The portfolio of available treatment options for food allergies is increasing but several relevant unmet needs remain. This review aims to provide a brief overview of the existing and future treatment options for IgE-mediated food allergies.
综述目的
本综述旨在概述目前及未来针对食物过敏儿童的治疗选择，重点介绍最新研究成果以及这些新方法对改善患者及其护理人员生活质量的潜在影响。
最新发现
在过去十年中，出现了许多有前景的方法，可替代标准的避免食用致敏食物的方法，因为后者存在严重意外反应的风险。口服免疫疗法脱敏已作为一种治疗方法引入临床，最近奥马珠单抗也被引入。此外，正在研究免疫疗法的其他给药途径、其他生物制剂、小分子、益生菌或益生元、微生物群移植疗法、IGNX001和PVX108。
总结
食物过敏的可用治疗选择组合正在增加，但仍有一些相关的未满足需求。本综述旨在简要概述IgE介导的食物过敏的现有和未来治疗选择。
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