全基因组关联研究确定了与儿童哮喘和特应性皮炎共病相关的CACNA2D3基因。 - Suppr

GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children.

作者信息

Kim Dong Yun, Lee Soyeon, Jung Jae Hwa, Sub Yujin, Lee Sumin, Kim Eun Gyul, Kim Mi Na, Kim Soo Yeon, Kim Yoon Hee, Sohn Myung Hyun, Gee Heon Yung, Kim Kyung Won

机构信息

Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.

Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Allergy. 2025 Jun;80(6):1776-1781. doi: 10.1111/all.16483. Epub 2025 Jan 27.

DOI:10.1111/all.16483

PMID:39868909

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12186590/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10dc/12186590/61fa536fc38a/ALL-80-1776-g001.jpg

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GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children.全基因组关联研究确定了与儿童哮喘和特应性皮炎共病相关的CACNA2D3基因。

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Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema.鉴定OCA2作为哮喘合并湿疹共病的一个新位点。

Clin Exp Allergy. 2022 Jan;52(1):70-81. doi: 10.1111/cea.13972. Epub 2021 Jul 3.

Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use.尽管使用吸入性皮质类固醇，哮喘加重的全基因组关联研究。

Eur Respir J. 2021 May 13;57(5). doi: 10.1183/13993003.03388-2020. Print 2021 May.

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.新的肺功能遗传信号突出了多种血统中的途径和慢性阻塞性肺疾病的关联。

Nat Genet. 2019 Mar;51(3):481-493. doi: 10.1038/s41588-018-0321-7. Epub 2019 Feb 25.

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Cell Calcium. 2018 Sep;74:131-143. doi: 10.1016/j.ceca.2018.07.003. Epub 2018 Jul 10.

Allergens stimulate store-operated calcium entry and cytokine production in airway epithelial cells.过敏原刺激气道上皮细胞中的钙库操纵性钙内流和细胞因子产生。

Sci Rep. 2016 Sep 8;6:32311. doi: 10.1038/srep32311.

Meta-analysis identifies seven susceptibility loci involved in the atopic march.荟萃分析确定了七个与特应性进程相关的易感基因座。

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GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children.

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