慢性袋炎的治疗方法

Approach to Therapy for Chronic Pouchitis.

作者信息

Kayal Maia, Boland Brigid

机构信息

Department of Medicine, Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; email:

Department of Medicine, University of California San Diego, La Jolla, California, USA.

出版信息

Annu Rev Med. 2025 Jan;76(1):167-173. doi: 10.1146/annurev-med-032224-120544.

DOI:10.1146/annurev-med-032224-120544

PMID:39869428

Abstract

Chronic pouchitis (CP) occurs in approximately 20% of patients with ulcerative colitis after total proctocolectomy with ileal pouch anal anastomosis and is categorized as antibiotic dependent, antibiotic refractory, or Crohn's disease-like. The management of CP is challenging because of limited evidence and few randomized controlled trials. In this review, we discuss the medical management of CP and its supporting data delineated by type of therapy.

摘要

慢性袋炎（CP）发生在约20%接受全直肠结肠切除回肠储袋肛管吻合术的溃疡性结肠炎患者中，可分为抗生素依赖型、抗生素难治型或克罗恩病样。由于证据有限且随机对照试验较少，CP的管理具有挑战性。在本综述中，我们讨论了CP的药物治疗及其按治疗类型划分的支持数据。