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老年人及慢性疾病患者的呼吸道合胞病毒疫苗接种:葡萄牙肺病学会、葡萄牙普通与家庭医学协会、葡萄牙心脏病学会、葡萄牙传染病与临床微生物学会、葡萄牙内分泌学、糖尿病与代谢学会以及葡萄牙内科学会的立场文件

Respiratory syncytial virus vaccination in older adults and patients with chronic disorders: A position paper from the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Endocrinology, Diabetes and Metabolism, and the Portuguese Society of Internal Medicine.

作者信息

Alfaro Tiago, Froes Filipe, Vicente Cláudia, Costa Rui, Gavina Cristina, Baptista Rui, Maio António, da Cunha Saraiva, Neves João Sérgio, Leuschner Pedro, Duque Sofia, Pinto Paula

机构信息

Portuguese Society of Pulmonology (SPP), Lisbon, Portugal.

Department of Pulmonology, Unidade Local de Saúde de Coimbra, E.P.E, Coimbra, Portugal.

出版信息

Pulmonology. 2025 Dec 31;31(1):2451456. doi: 10.1080/25310429.2025.2451456. Epub 2025 Jan 27.

Abstract

BACKGROUND

Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection, hospitalisation and death in adults.

METHODS

Based on evidence regarding the impact of RSV on adult populations at risk for severe infection and the efficacy and safety of RSV vaccines, the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Endocrinology, Diabetes and Metabolism, and the Portuguese Society of Internal Medicine endorses this position paper with recommendations to prevent RSV-associated disease and its complications in adults through vaccination.

CONCLUSION

The RSV vaccine is recommended for people aged ≥50 years with risk factors (chronic obstructive pulmonary disease, asthma, heart failure, coronary artery disease, diabetes, chronic kidney disease, chronic liver disease, immunocompromise, frailty, dementia, and residence in a nursing home) and all persons aged ≥60 years. If it cannot be made available to this population, then the vaccine should be prioritised for individuals aged ≥75 years and those aged ≥50 years with risk factors. The vaccine should preferably be given between September and November and can be co-administered with the influenza vaccine. Ongoing studies on RSV vaccines may justify extending these recommendations in the future.

摘要

背景

呼吸道合胞病毒(RSV)是成人下呼吸道感染、住院和死亡的重要原因。

方法

基于有关RSV对严重感染风险成人人群的影响以及RSV疫苗的疗效和安全性的证据,葡萄牙肺病学会、葡萄牙普通与家庭医学协会、葡萄牙心脏病学会、葡萄牙传染病与临床微生物学会、葡萄牙内分泌学、糖尿病与代谢学会以及葡萄牙内科学会认可本立场文件,并提出通过接种疫苗预防成人RSV相关疾病及其并发症的建议。

结论

建议为年龄≥50岁且有风险因素(慢性阻塞性肺疾病、哮喘、心力衰竭、冠状动脉疾病、糖尿病、慢性肾病、慢性肝病、免疫功能低下、虚弱、痴呆以及居住在养老院)的人群以及所有年龄≥60岁的人群接种RSV疫苗。如果无法为该人群提供疫苗,则应优先为年龄≥75岁的个体以及年龄≥50岁且有风险因素的个体接种。疫苗最好在9月至11月期间接种,并且可以与流感疫苗同时接种。正在进行的RSV疫苗研究可能在未来证明扩大这些建议的合理性。

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