Matsuzawa Yasushi, Tsujita Kenichi
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Hypertens Res. 2025 Apr;48(4):1636-1638. doi: 10.1038/s41440-025-02115-0. Epub 2025 Jan 28.
Balance between Protective vs. Exacerbating Effects of ACEIs and ARBs in Omicron Variant Infections. The spike protein on the surface of the Omicron variant has a high affinity for ACE2, making it more prone to enter cells and induce ACE2 downregulation. Therefore, the effects of ACEIs and ARBs on Omicron variant infections may differ from those of the previous variants. The current study demonstrates that ACEIs and ARBs do not aggravate or prolong COVID-19 due to Omicron variant infections.
血管紧张素转换酶抑制剂（ACEIs）和血管紧张素Ⅱ受体阻滞剂（ARBs）在奥密克戎变异株感染中的保护作用与加重作用的平衡。奥密克戎变异株表面的刺突蛋白对血管紧张素转换酶2（ACE2）具有高亲和力，使其更容易进入细胞并诱导ACE2下调。因此，ACEIs和ARBs对奥密克戎变异株感染的影响可能与之前的变异株不同。当前研究表明，ACEIs和ARBs不会因奥密克戎变异株感染而加重或延长新冠病毒疾病（COVID-19）。
