Kazinczi Csaba, Szepfalusi Noemi, Nemeth Viola Luca, Holczer Adrienn, Jakab Katalin, Vecsei Laszlo, Klivenyi Peter, Must Anita, Racsmany Mihaly
Department of Neurology, University of Szeged, 6, Semmelweis Street, Szeged, 6725, Hungary.
Department of Clinical Psychology, Semmelweis University, 25, Üllői Street, Budapest, 1091, Hungary.
BMC Neurol. 2025 Jan 27;25(1):38. doi: 10.1186/s12883-025-04042-6.
Recent research has highlighted the role of fronto-parietal brain networks and cognitive control in mood disorders. Transcranial direct current stimulation (tDCS) and computer-based cognitive training are used in post-stroke rehabilitation. This study examined the combined effects ofof computer-based inhibitory control training (ICCT) and anodal tDCS on post-stroke depression and anxiety.
Thirty-five participants were randomly assigned to one of three groups: active tDCS treatment (A), sham tDCS treatment with ICCT (T), or active tDCS with ICCT (AT), for a duration of ten days. Primary outcome measures included the Beck Depression Inventory (BDI), Hamilton Depression Rating Scale (HAM-D), and Spielberger's State-Trait Anxiety Inventory (STAI-S/T). Statistical analysis was performed using a Mixed-model Analysis of Variance, with supplementary Bayesian analysis.
The AT group showed a significant improvement in BDI scores (p < .001), whereas no significant effects were observed on the HAM-D, STAI-T, or STAI-S scales.
The combination of tDCS and ICCT reduced depressive symptoms as measured by the BDI; while no significant effects were found with either treatment alone. Further research is needed to explore the mechanisms behind the synergistic effects in the treatment of post-stroke mood disorders.
近期研究强调了额顶叶脑网络和认知控制在情绪障碍中的作用。经颅直流电刺激（tDCS）和基于计算机的认知训练被用于中风后康复。本研究考察了基于计算机的抑制控制训练（ICCT）和阳极tDCS对中风后抑郁和焦虑的联合作用。
35名参与者被随机分配到三组中的一组：主动tDCS治疗组（A）、接受ICCT的假tDCS治疗组（T）或接受ICCT的主动tDCS治疗组（AT），为期10天。主要结局指标包括贝克抑郁量表（BDI）、汉密尔顿抑郁评定量表（HAM-D）和斯皮尔伯格状态-特质焦虑量表（STAI-S/T）。采用混合模型方差分析进行统计分析，并辅以贝叶斯分析。
AT组的BDI评分有显著改善（p < 0.001），而在HAM-D、STAI-T或STAI-S量表上未观察到显著效果。
tDCS与ICCT联合使用可降低BDI所测量的抑郁症状；而单独使用任何一种治疗方法均未发现显著效果。需要进一步研究以探索治疗中风后情绪障碍时协同效应背后的机制。
