Manhas Neha, Kumar Gobind, Dhawan Sanjeev, Makhanya Talent, Singh Parvesh
Department of Chemistry, Durban University of Technology, ML Sultan Campus, Durban, 4000, South Africa.
School of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, 4000, South Africa.
ChemistryOpen. 2025 Jul;14(7):e202400439. doi: 10.1002/open.202400439. Epub 2025 Jan 28.
Quinazolines/quinazolin-4-ones are significant nitrogen-containing heterocycles that exist in various natural products and synthetic scaffolds with diverse medicinal and pharmacological applications. Researchers across the globe have explored numerous synthetic strategies to develop safer and more potent quinazoline/quinazolinone analogues, particularly for combating cancer and microbial infections. This review systematically examines scholarly efforts toward understanding this scaffold's synthetic pathways and medicinal relevance, emphasizing the role of metal and non-metal catalysts and other reagents in their synthesis. Additionally, the article discusses selected compounds' anticancer and antimicrobial properties, with a brief look into their structure-activity relationships.
喹唑啉/喹唑啉-4-酮是重要的含氮杂环化合物，存在于各种天然产物和具有不同医学和药理学应用的合成骨架中。全球的研究人员已经探索了许多合成策略，以开发更安全、更有效的喹唑啉/喹唑啉酮类似物，特别是用于对抗癌症和微生物感染。这篇综述系统地审视了在理解该骨架的合成途径和医学相关性方面的学术成果，强调了金属和非金属催化剂以及其他试剂在其合成中的作用。此外，本文还讨论了所选化合物的抗癌和抗菌特性，并简要探讨了它们的构效关系。
