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创新诊断工具助力非酒精性肝硬化患者轻微肝性脑病的筛查。

Innovative diagnostic tool aids screening for minimal hepatic encephalopathy in non-alcoholic cirrhosis patients.

作者信息

Li Ting, Li Ya-Ping

机构信息

Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an 710004, Shaanxi Province, China.

出版信息

World J Hepatol. 2025 Jan 27;17(1):101420. doi: 10.4254/wjh.v17.i1.101420.

DOI:10.4254/wjh.v17.i1.101420
PMID:39871897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11736476/
Abstract

In this editorial we comment on the article by Jiang . We focus on the EncephalApp Stroop test which is an innovative, smartphone-based tool specifically designed for screening minimal hepatic encephalopathy (MHE) in cirrhosis patients. Traditional MHE screening methods, while highly sensitive and specific, are often complex, time-consuming, and require controlled environmental conditions, limiting their widespread clinical use. The EncephalApp Stroop test simplifies the screening process, enhances diagnostic efficiency, and is applicable across diverse cultural contexts. However, the combination of additional biomarkers could further improve diagnostic accuracy. Despite its promising potential, more multicenter clinical studies are required to validate its effectiveness and applicability on a global scale.

摘要

在这篇社论中,我们对蒋的文章进行评论。我们关注的是EncephalApp斯特鲁普测试,这是一种创新的、基于智能手机的工具,专门设计用于筛查肝硬化患者的轻微肝性脑病(MHE)。传统的MHE筛查方法虽然具有高度的敏感性和特异性,但往往复杂、耗时,且需要可控的环境条件,这限制了它们在临床上的广泛应用。EncephalApp斯特鲁普测试简化了筛查过程,提高了诊断效率,并且适用于不同的文化背景。然而,结合其他生物标志物可能会进一步提高诊断准确性。尽管其潜力巨大,但仍需要更多的多中心临床研究来在全球范围内验证其有效性和适用性。

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本文引用的文献

1
External validation of EncephalApp Stroop test to screen minimal hepatic encephalopathy patients with nonalcoholic cirrhosis.用于筛查非酒精性肝硬化所致轻微肝性脑病患者的EncephalApp斯特鲁普测试的外部验证
World J Hepatol. 2024 Dec 27;16(12):1450-1457. doi: 10.4254/wjh.v16.i12.1450.
2
Minimal hepatic encephalopathy is associated with a higher risk of overt hepatic encephalopathy and poorer survival.轻微肝性脑病与显性肝性脑病风险较高及生存率较低相关。
J Intern Med. 2024 Mar;295(3):331-345. doi: 10.1111/joim.13747. Epub 2023 Nov 20.
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EncephalApp Stroop Test for covert hepatic encephalopathy screening in Tunisian cirrhotic patients.EncephalApp 斯特鲁普测验用于突尼斯肝硬化患者隐匿性肝性脑病的筛查。
F1000Res. 2023 Sep 1;11:686. doi: 10.12688/f1000research.121781.2. eCollection 2022.
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Predicting overt hepatic encephalopathy after TIPS: Value of three minimal hepatic encephalopathy tests.经颈静脉肝内门体分流术后显性肝性脑病的预测:三种轻微肝性脑病检测方法的价值
JHEP Rep. 2023 Jun 28;5(9):100829. doi: 10.1016/j.jhepr.2023.100829. eCollection 2023 Sep.
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Targeted metabolomics reveals serum changes of amino acids in mild to moderate ischemic stroke and stroke mimics.靶向代谢组学揭示轻度至中度缺血性中风及类中风患者血清氨基酸变化。
Front Neurol. 2023 Apr 14;14:1153193. doi: 10.3389/fneur.2023.1153193. eCollection 2023.
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Prevalence of Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis: A Multicenter Study.肝硬化患者轻微型肝性脑病的患病率:一项多中心研究。
Am J Gastroenterol. 2023 Dec 1;118(12):2191-2200. doi: 10.14309/ajg.0000000000002251. Epub 2023 Mar 20.
7
EncephalApp Stroop Test validation for the screening of minimal hepatic encephalopathy in Brazil.EncephalApp斯特鲁普测试在巴西用于筛查轻微肝性脑病的验证。
Ann Hepatol. 2022 Jan-Feb;27(1):100543. doi: 10.1016/j.aohep.2021.100543. Epub 2021 Sep 24.
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Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy.基于认知追踪的轻微肝性脑病诊断与治疗策略
Metab Brain Dis. 2020 Aug;35(6):869-881. doi: 10.1007/s11011-020-00539-w. Epub 2020 Jun 3.
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Quality of life in patients with minimal hepatic encephalopathy.轻微肝性脑病患者的生活质量。
World J Gastroenterol. 2018 Dec 28;24(48):5446-5453. doi: 10.3748/wjg.v24.i48.5446.
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Cognitive Screening Tests Versus Comprehensive Neuropsychological Test Batteries: A National Academy of Neuropsychology Education Paper†.认知筛查测试与综合神经心理测试组合:美国神经心理学学会教育论文†
Arch Clin Neuropsychol. 2017 Jun 1;32(4):491-498. doi: 10.1093/arclin/acx021.