Xu Xiao-Tong, Jiang Min-Jie, Fu Yun-Lai, Xie Fang, Li Jian-Jun, Meng Qing-Hua
Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
Interventional Therapy Center for Oncology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
World J Hepatol. 2025 Jan 27;17(1):100377. doi: 10.4254/wjh.v17.i1.100377.
The gut microbiome is associated with hepatic encephalopathy (HE), but research results on the gut microbiome characteristics of patients with liver cirrhosis with and without HE are inconsistent.
To study the gut microbiota characteristics of patients with liver cirrhosis with and without HE.
We searched the PubMed, Web of Science, EMBASE, and Cochrane databases using two keywords, HE, and gut microbiome. According to the inclusion and exclusion criteria, suitable literature was screened to extract data on the diversity and composition of the fecal microbiota in patients with liver cirrhosis with and without HE. The data were analyzed using RevMan and STATA.
Seventeen studies were included: (1) A meta-analysis of 7 studies revealed that the Shannon index in liver cirrhosis patients with HE was significantly lower than that in patients without HE [-0.20, 95% confidence interval (CI): -0.28 to -0.13, = 20%]; (2) The relative abundances of (-2.73, 95%CI: -4.58 to -0.87, = 38%) and (-2.93, 95%CI: -4.29 to -1.56, = 0%) in liver cirrhosis patients with HE was significantly lower than those in patients without HE; (3) In patients with HE, , , , and proportions increased, but , , , and proportions decreased; (4) Differences in the fecal metabolome between liver cirrhosis patients with and without HE were detected; and (5) Differential gut microbiomes may serve as diagnostic and prognostic tools.
The gut microbiomes of patients with liver cirrhosis with and without HE differ. Some gut microbiomes may distinguish liver cirrhosis patients with or without HE and determine patient prognosis.
肠道微生物群与肝性脑病（HE）相关，但关于伴有和不伴有HE的肝硬化患者肠道微生物群特征的研究结果并不一致。
研究伴有和不伴有HE的肝硬化患者的肠道微生物群特征。
我们使用两个关键词“HE”和“肠道微生物群”在PubMed、Web of Science、EMBASE和Cochrane数据库中进行检索。根据纳入和排除标准，筛选合适的文献以提取伴有和不伴有HE的肝硬化患者粪便微生物群多样性和组成的数据。使用RevMan和STATA对数据进行分析。
纳入了17项研究：（1）对7项研究的荟萃分析显示，伴有HE的肝硬化患者的香农指数显著低于不伴有HE的患者[-0.20，95%置信区间（CI）：-0.28至-0.13，I² = 20%]；（2）伴有HE的肝硬化患者中，[X]（-2.73，95%CI：-4.58至-0.87，I² = 38%）和[X]（-2.93，95%CI：-4.29至-1.56，I² = 0%）的相对丰度显著低于不伴有HE的患者；（3）在伴有HE的患者中，[X]、[X]、[X]和[X]的比例增加，但[X]、[X]、[X]和[X]的比例降低；（4）检测到伴有和不伴有HE的肝硬化患者粪便代谢组存在差异；（5）不同的肠道微生物群可能作为诊断和预后工具。
伴有和不伴有HE的肝硬化患者的肠道微生物群不同。一些肠道微生物群可能区分伴有或不伴有HE的肝硬化患者并确定患者预后。
