Sun Man, Zhou Huan, Zang Dan, Liu Chen-Guang, Chen Jun
Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Front Oncol. 2025 Jan 13;14:1417936. doi: 10.3389/fonc.2024.1417936. eCollection 2024.
Toxic epidermal necrolysis (TEN) is a rare and serious skin reaction. This study reports a case of a patient with lung adenocarcinoma (LUAD) who developed severe TEN after 8 days of treatment with Camrelizumab monotherapy. The patient's condition was effectively relieved with high-dose corticosteroids and intravenous immunoglobulin therapy. The diagnosis and treatment of immune-related TEN are challenging. This is a rare and severe case of TEN associated with the use of Camrelizumab. Additionally, we provide an in-depth understanding of immune-related TEN, summarizing its characteristics and treatment progress through a literature review, aiming to provide reference for the clinical safe application of immune checkpoint inhibitors (ICIs).
中毒性表皮坏死松解症（TEN）是一种罕见且严重的皮肤反应。本研究报告了一例肺腺癌（LUAD）患者，在接受卡瑞利珠单抗单药治疗8天后发生了严重的TEN。该患者的病情通过大剂量糖皮质激素和静脉注射免疫球蛋白治疗得到有效缓解。免疫相关TEN的诊断和治疗具有挑战性。这是一例与使用卡瑞利珠单抗相关的罕见且严重的TEN病例。此外，我们通过文献综述对免疫相关TEN进行了深入了解，总结了其特征和治疗进展，旨在为免疫检查点抑制剂（ICIs）的临床安全应用提供参考。
