• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Transglutaminase-crosslinked extracellular matrix in cirrhotic liver tissues provides pro-fibrotic mechano-microenvironment for cells.

作者信息

Lyu Cheng, Kong Wenyu, Zhang Yan, Liu Zhiqiang, Liang Kaini, Du Yanan

机构信息

Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.

出版信息

Life Med. 2023 Aug 23;2(6):lnad030. doi: 10.1093/lifemedi/lnad030. eCollection 2023 Dec.

DOI:10.1093/lifemedi/lnad030
PMID:39872061
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11748972/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84fa/11748972/24f9bbf1e7c4/lnad030_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84fa/11748972/a0fbf6c7fbbc/lnad030_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84fa/11748972/24f9bbf1e7c4/lnad030_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84fa/11748972/a0fbf6c7fbbc/lnad030_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84fa/11748972/24f9bbf1e7c4/lnad030_fig2.jpg

相似文献

1
Transglutaminase-crosslinked extracellular matrix in cirrhotic liver tissues provides pro-fibrotic mechano-microenvironment for cells.肝硬化肝组织中经转谷氨酰胺酶交联的细胞外基质为细胞提供促纤维化机械微环境。
Life Med. 2023 Aug 23;2(6):lnad030. doi: 10.1093/lifemedi/lnad030. eCollection 2023 Dec.
2
Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma.细胞外基质组成对肝癌仿生体外模型中肿瘤细胞行为的影响。
Sci Rep. 2023 Jan 13;13(1):748. doi: 10.1038/s41598-023-27997-3.
3
Transglutaminase-mediated cross-linking is involved in the stabilization of extracellular matrix in human liver fibrosis.转谷氨酰胺酶介导的交联参与人类肝纤维化中细胞外基质的稳定过程。
J Hepatol. 2001 Sep;35(3):367-75. doi: 10.1016/s0168-8278(01)00135-0.
4
Engineering and Monitoring 3D Cell Constructs with Time-Evolving Viscoelasticity for the Study of Liver Fibrosis In Vitro.构建并监测具有随时间演变的粘弹性的3D细胞结构用于体外肝纤维化研究
Bioengineering (Basel). 2021 Jul 27;8(8):106. doi: 10.3390/bioengineering8080106.
5
Fibrotic liver extracellular matrix induces cancerous phenotype in biomimetic micro-tissues of hepatocellular carcinoma model.纤维化肝细胞外基质在肝细胞癌模型的仿生微组织中诱导癌性表型。
Hepatobiliary Pancreat Dis Int. 2025 Feb;24(1):92-103. doi: 10.1016/j.hbpd.2024.09.003. Epub 2024 Sep 7.
6
Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition.肝硬化人肝细胞外基质 3D 支架促进 Smad 依赖性 TGF-β1 上皮间充质转化。
Cells. 2019 Dec 28;9(1):83. doi: 10.3390/cells9010083.
7
An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition.使用交联天然细胞外基质衍生水凝胶构建纤维化的体外模型，在不改变组成的情况下调节生物力学。
Acta Biomater. 2022 Jul 15;147:50-62. doi: 10.1016/j.actbio.2022.05.031. Epub 2022 May 21.
8
'Tissue' transglutaminase release from apoptotic cells into extracellular matrix during human liver fibrogenesis.
J Pathol. 1999 Sep;189(1):92-8. doi: 10.1002/(SICI)1096-9896(199909)189:1<92::AID-PATH386>3.0.CO;2-B.
9
Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma.肝硬化细胞外基质通过在肝细胞癌中启动免疫抑制性中性粒细胞胞外陷阱形成来减弱αPD-1治疗反应。
Exp Hematol Oncol. 2024 Feb 22;13(1):20. doi: 10.1186/s40164-024-00476-9.
10
[Control of hepatocellular carcinoma progression by the tumor microenvironment].肿瘤微环境对肝细胞癌进展的调控
Bull Acad Natl Med. 2012 Jan;196(1):75-84.

本文引用的文献

1
Advanced glycation end-products as mediators of the aberrant crosslinking of extracellular matrix in scarred liver tissue.晚期糖基化终产物作为细胞外基质异常交联的介质在瘢痕肝组织中的作用。
Nat Biomed Eng. 2023 Nov;7(11):1437-1454. doi: 10.1038/s41551-023-01019-z. Epub 2023 Apr 10.
2
Collagen crosslinking: effect on structure, mechanics and fibrosis progression.胶原蛋白交联：对结构、力学性能及纤维化进展的影响
Biomed Mater. 2021 Oct 19;16(6). doi: 10.1088/1748-605X/ac2b79.
3
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis.
单细胞转录组学揭示肝硬化时肝窦内皮细胞的区域特异性改变。
Cell Mol Gastroenterol Hepatol. 2021;11(4):1139-1161. doi: 10.1016/j.jcmgh.2020.12.007. Epub 2020 Dec 16.
4
YAP-mediated mechanotransduction tunes the macrophage inflammatory response.YAP 介导电力学转导调节巨噬细胞炎症反应。
Sci Adv. 2020 Dec 4;6(49). doi: 10.1126/sciadv.abb8471. Print 2020 Dec.
5
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.解析人肝硬化的纤维性龛位于单细胞水平。
Nature. 2019 Nov;575(7783):512-518. doi: 10.1038/s41586-019-1631-3. Epub 2019 Oct 9.
6
Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials.靶向细胞外基质硬度以减轻疾病：从分子机制到临床试验。
Sci Transl Med. 2018 Jan 3;10(422). doi: 10.1126/scitranslmed.aao0475.
7
Extracellular matrix as a driver of progressive fibrosis.细胞外基质作为进行性纤维化的驱动因素。
J Clin Invest. 2018 Jan 2;128(1):45-53. doi: 10.1172/JCI93557.
8
Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis.力学转导调控的纤维化微环境揭示了血管生成在肝纤维化中的作用。
Nat Mater. 2017 Dec;16(12):1252-1261. doi: 10.1038/nmat5024. Epub 2017 Nov 13.
9
Roles of YAP in mediating endothelial cell junctional stability and vascular remodeling.YAP在介导内皮细胞连接稳定性和血管重塑中的作用。
BMB Rep. 2015 Aug;48(8):429-30. doi: 10.5483/bmbrep.2015.48.8.146.
10
Liver fibrosis and repair: immune regulation of wound healing in a solid organ.肝纤维化与修复：实体器官中创伤愈合的免疫调控。
Nat Rev Immunol. 2014 Mar;14(3):181-94. doi: 10.1038/nri3623.