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RhoA/ROCK1/YAP/F-肌动蛋白的下调导致主动脉平滑肌细胞硬度降低，促进主动脉夹层形成。

Downregulation of RhoA/ROCK1/YAP/F-actin causing decreased aortic smooth muscle cell stiffness promotes aortic dissection formation.

作者信息

Zhang Wei, Wang Mengxiao, Wang Enci, Lu Wei, Li Zengxia, Zhang Yuchong, Hu Gaofei, Zhang Qi, Shan Wenxin, Dang Yongjun, Zhao Zhe, Zheng Lemin, Fu Weiguo, Wang Lixin

机构信息

Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Vascular Surgery Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

出版信息

Life Metab. 2024 Jun 3;3(5):loae022. doi: 10.1093/lifemeta/loae022. eCollection 2024 Oct.

DOI:10.1093/lifemeta/loae022
PMID:39872140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749839/
Abstract

Downregulated RhoA/ROCK1/YAP/F-actin axis leads to decreased AoSMC stiffness and promotes AD formation.

摘要

RhoA/ROCK1/YAP/丝状肌动蛋白轴下调导致主动脉平滑肌细胞硬度降低并促进主动脉夹层形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b1/11749839/36f0cc5f0146/loae022_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b1/11749839/6076f9bb20b1/loae022_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b1/11749839/36f0cc5f0146/loae022_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b1/11749839/6076f9bb20b1/loae022_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b1/11749839/36f0cc5f0146/loae022_fig1.jpg

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Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):234-252. doi: 10.1161/ATVBAHA.122.318135. Epub 2022 Dec 29.
2
Legumain Is an Endogenous Modulator of Integrin αvβ3 Triggering Vascular Degeneration, Dissection, and Rupture.组织蛋白酶 S 是整合素 αvβ3 触发血管退行性变、夹层和破裂的内源性调节剂。
Circulation. 2022 Mar;145(9):659-674. doi: 10.1161/CIRCULATIONAHA.121.056640. Epub 2022 Jan 31.
3
Loss of smooth muscle α-actin effects on mechanosensing and cell-matrix adhesions.
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Exp Biol Med (Maywood). 2020 Feb;245(4):374-384. doi: 10.1177/1535370220903012. Epub 2020 Feb 17.
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YAP and TAZ regulate cell volume.YAP 和 TAZ 调节细胞体积。
J Cell Biol. 2019 Oct 7;218(10):3472-3488. doi: 10.1083/jcb.201902067. Epub 2019 Sep 3.
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