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Metabolic orchestration of drug-tolerant persister cells in cancer.

作者信息

Nie Meng, Hu Zeping

机构信息

School of Pharmaceutical Sciences, Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China.

School of Public Health, Capital Medical University, Beijing 100069, China.

出版信息

Life Med. 2024 Dec 7;3(6):lnae040. doi: 10.1093/lifemedi/lnae040. eCollection 2024 Dec.

DOI:10.1093/lifemedi/lnae040
PMID:39872154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11748267/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad4b/11748267/ef7678742048/lnae040_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad4b/11748267/ef7678742048/lnae040_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad4b/11748267/ef7678742048/lnae040_fig1.jpg

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本文引用的文献

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Cancer drug-tolerant persister cells: from biological questions to clinical opportunities.癌症耐药性休眠细胞：从生物学问题到临床机遇。
Nat Rev Cancer. 2024 Oct;24(10):694-717. doi: 10.1038/s41568-024-00737-z. Epub 2024 Sep 2.
2
Cellular adaptation to cancer therapy along a resistance continuum.细胞沿着抵抗连续体适应癌症治疗。
Nature. 2024 Jul;631(8022):876-883. doi: 10.1038/s41586-024-07690-9. Epub 2024 Jul 10.
3
FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy.FOXO1介导的脂质代谢维持哺乳动物胚胎处于休眠状态。
Nat Cell Biol. 2024 Feb;26(2):181-193. doi: 10.1038/s41556-023-01325-3. Epub 2024 Jan 4.
4
Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse.靶向乙酰胆碱信号转导可调节 EGFR 突变型肺癌的持续药物耐受并阻碍肿瘤复发。
J Clin Invest. 2022 Oct 17;132(20):e160152. doi: 10.1172/JCI160152.
5
Cycling cancer persister cells arise from lineages with distinct programs.循环肿瘤干细胞由具有不同特性的细胞谱系产生。
Nature. 2021 Aug;596(7873):576-582. doi: 10.1038/s41586-021-03796-6. Epub 2021 Aug 11.
6
Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy.结直肠癌细胞进入休眠样 DTP 状态以耐受化疗。
Cell. 2021 Jan 7;184(1):226-242.e21. doi: 10.1016/j.cell.2020.11.018.
7
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation.黑色素瘤休眠细胞通过 ACOX1 介导的脂肪酸氧化对 BRAF/MEK 抑制剂具有耐受性。
Cell Rep. 2020 Nov 24;33(8):108421. doi: 10.1016/j.celrep.2020.108421.
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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.耐药物持久性癌细胞易受谷胱甘肽过氧化物酶4（GPX4）抑制的影响。
Nature. 2017 Nov 9;551(7679):247-250. doi: 10.1038/nature24297. Epub 2017 Nov 1.
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The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation.癌症干细胞标志物醛脱氢酶需要维持一个具有药物耐受能力的肿瘤细胞亚群。
Cancer Res. 2014 Jul 1;74(13):3579-90. doi: 10.1158/0008-5472.CAN-13-3456. Epub 2014 May 8.
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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.肿瘤细胞亚群中染色质介导的可逆药物耐受状态。
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