Bevilacqua Alessio, Ho Ping-Chih, Franco Fabien
Department of Fundamental Oncology, University of Lausanne, 1007 Lausanne, Switzerland.
Ludwig Institute for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland.
Life Metab. 2023 Jun 28;2(5):load028. doi: 10.1093/lifemeta/load028. eCollection 2023 Oct.
Aging represents an emerging challenge for public health due to the declined immune responses against pathogens, weakened vaccination efficacy, and disturbed tissue homeostasis. Metabolic alterations in cellular and systemic levels are also known to be cardinal features of aging. Moreover, cellular metabolism has emerged to provide regulations to guide immune cell behavior via modulations on signaling cascades and epigenetic landscape, and the aberrant aging process in immune cells can lead to inflammaging, a chronic and low-grade inflammation that facilitates aging by perturbing homeostasis in tissues and organs. Here, we review how the metabolic program in T cells is influenced by the aging process and how aged T cells modulate inflammaging. In addition, we discuss the potential approaches to reverse or ameliorate aging by rewiring the metabolic programming of immune cells.
衰老对公共卫生构成了新的挑战，原因在于对病原体的免疫反应下降、疫苗接种效果减弱以及组织稳态紊乱。细胞和全身水平的代谢改变也是衰老的主要特征。此外，细胞代谢已被发现可通过调节信号级联反应和表观遗传格局来指导免疫细胞行为，免疫细胞异常的衰老过程会导致炎症衰老，即一种慢性低度炎症，通过扰乱组织和器官的稳态促进衰老。在此，我们综述了衰老过程如何影响T细胞中的代谢程序，以及衰老的T细胞如何调节炎症衰老。此外，我们还讨论了通过重新调整免疫细胞的代谢程序来逆转或改善衰老的潜在方法。
