Shi Binbing, Wang Xiaotong, Xue Tongneng, Liu Jie, Wu Wanling, Luo Yuanyuan, Zhu Hong, Pan Defeng
Department of General Practice, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Department of Cardiology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000, China.
Int J Cardiol Cardiovasc Risk Prev. 2025 Jan 10;24:200367. doi: 10.1016/j.ijcrp.2025.200367. eCollection 2025 Mar.
To investigate the association between plasma miR-146a expression levels, severity of coronary lesions, and clinical prognosis in patients with unstable angina pectoris (UAP).
A total of 100 patients with UAP and 100 controls were selected for assessment of plasma miRNA-146a expression levels. We assessed the severity of coronary lesions in patients with UAP using the Gensini score. Additionally, we analyzed the correlation between miR-146a expression and the degree of coronary artery stenosis in patients with UAP. The incidence of major adverse cardiovascular events (MACEs) was followed-up for 48 months after hospitalization and discharge. The median grouping method was employed to categorize patients into high- and low-expression groups based on their miR-146a levels. Thereafter, the incidence of MACEs in these groups was analyzed using the Kaplan-Meier method.
The plasma expression level of miR-146a in the UAP group was 1.8-fold greater than that in the control group (Z = 6.970, P < 0.001) and correlated with the severity of coronary lesions; a high expression level was associated with a higher Gensini score (P < 0.05). Patients with high miR-146a expression levels showed a significantly higher incidence of MACEs than those with low miR-146a expression levels (log-rank test: P = 0.004).
Plasma miR-146a expression levels in patients with UAP correlated with the severity of coronary lesions, and patients with high miR-146a expression levels had poorer clinical prognoses than those with lower expression levels.
探讨不稳定型心绞痛（UAP）患者血浆miR-146a表达水平、冠状动脉病变严重程度与临床预后之间的关系。
选取100例UAP患者和100例对照者，评估血浆miRNA-146a表达水平。我们使用Gensini评分评估UAP患者冠状动脉病变的严重程度。此外，分析UAP患者miR-146a表达与冠状动脉狭窄程度之间的相关性。住院和出院后对主要不良心血管事件（MACE）的发生率进行48个月的随访。采用中位数分组法，根据患者的miR-146a水平将其分为高表达组和低表达组。此后，使用Kaplan-Meier法分析这些组中MACE的发生率。
UAP组血浆miR-146a表达水平比对照组高1.8倍（Z = 6.970，P < 0.001），且与冠状动脉病变严重程度相关；高表达水平与较高的Gensini评分相关（P < 0.05）。miR-146a表达水平高的患者MACE发生率显著高于miR-146a表达水平低的患者（对数秩检验：P = 0.004）。
UAP患者血浆miR-146a表达水平与冠状动脉病变严重程度相关，miR-146a表达水平高的患者临床预后比表达水平低的患者差。
