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NAD is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1.

作者信息

Wu Yi, Liu Yang, Hao Zhihong, Liu Xingguo

机构信息

CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.

Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, China-New Zealand Joint Laboratory on Biomedicine and Health, CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine, Institute for Stem Cell and Regeneration, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.

出版信息

Life Med. 2022 Oct 26;1(3):401-405. doi: 10.1093/lifemedi/lnac046. eCollection 2022 Dec.

DOI:10.1093/lifemedi/lnac046
PMID:39872750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749344/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c77/11749344/02503dc8c641/lnac046_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c77/11749344/b7ee58787dd8/lnac046_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c77/11749344/02503dc8c641/lnac046_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c77/11749344/b7ee58787dd8/lnac046_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c77/11749344/02503dc8c641/lnac046_fig2.jpg

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Cell Death Differ. 2022 Nov;29(11):2316-2331. doi: 10.1038/s41418-022-01018-8. Epub 2022 May 25.
2
NAD metabolism and its roles in cellular processes during ageing.NAD 代谢及其在衰老过程中细胞过程中的作用。
Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22.
3
Cellular metabolism and homeostasis in pluripotency regulation.
细胞代谢与多能性调控中的细胞内稳态
Protein Cell. 2020 Sep;11(9):630-640. doi: 10.1007/s13238-020-00755-1. Epub 2020 Jul 8.
4
Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells.烟酰胺腺嘌呤二核苷酸诱导人胚胎干细胞的二价代谢并维持其多能性。
Stem Cells. 2020 May;38(5):624-638. doi: 10.1002/stem.3152. Epub 2020 Feb 4.
5
Metabolic Regulation of Cell Fate and Function.细胞命运和功能的代谢调控。
Trends Cell Biol. 2020 Mar;30(3):201-212. doi: 10.1016/j.tcb.2019.12.005. Epub 2020 Jan 23.
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NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.烟酰胺腺嘌呤二核苷酸（NAD(+)）代谢与能量稳态的调控：线粒体与细胞核之间的平衡行为
Cell Metab. 2015 Jul 7;22(1):31-53. doi: 10.1016/j.cmet.2015.05.023. Epub 2015 Jun 25.
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