Wu Si-Jia, Wu Chu-Ying, Ye Kai
Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.
World J Gastrointest Surg. 2025 Jan 27;17(1):100232. doi: 10.4240/wjgs.v17.i1.100232.
Early recurrence (ER) following surgery for rectal cancer is a significant factor impacting patient survival rates. Tsai identified age, preoperative neoadjuvant therapy, length of hospital stay, tumour location, and pathological stage as factors influencing the risk of ER. Postoperative monitoring for ER should encompass a thorough medical history review, physical examination, tumour marker testing, and imaging studies. Additionally, noninvasive circulating tumour cell DNA testing can be utilized to predict ER. Treatment strategies may involve radical surgery, radiation therapy, chemotherapy, and immunotherapy. Through a comprehensive analysis of risk factors, the optimization of monitoring methods, and the development of personalized treatment strategies, it is anticipated that both the efficacy of treatment and the quality of life for rectal cancer patients with postoperative recurrence can be significantly improved.
直肠癌手术后的早期复发（ER）是影响患者生存率的重要因素。Tsai确定年龄、术前新辅助治疗、住院时间、肿瘤位置和病理分期为影响ER风险的因素。ER的术后监测应包括全面的病史回顾、体格检查、肿瘤标志物检测和影像学检查。此外，可利用非侵入性循环肿瘤细胞DNA检测来预测ER。治疗策略可能包括根治性手术、放射治疗、化疗和免疫治疗。通过对危险因素的综合分析、监测方法的优化以及个性化治疗策略的制定，预计术后复发的直肠癌患者的治疗效果和生活质量都能得到显著改善。
