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神经重症监护的当前进展。

Current advances in neurocritical care.

作者信息

Chen Yuqing, Wang Shuya, Xu Shanshan, Xu Ningyuan, Zhang Linlin, Zhou Jianxin

机构信息

Department of Critical Care Unit, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Department of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

出版信息

J Intensive Med. 2024 Jul 3;5(1):23-31. doi: 10.1016/j.jointm.2024.04.005. eCollection 2025 Jan.

Abstract

This review summarizes the current research advances and guideline updates in neurocritical care. For the therapy of ischemic stroke, the extended treatment time window for thrombectomy and the emergence of novel thrombolytic agents and strategies have brought greater hope for patient recovery. Minimally invasive hematoma evacuation and goal-directed bundled management have shown clinical benefits in treating cerebral hemorrhage. In the treatment of aneurysmal subarachnoid hemorrhage (aSAH), early lumbar drainage can reduce the risk of infarction. Decompressive craniectomy for severe traumatic brain injury has also obtained high-quality evidence support. However, multimodal brain monitoring strategies for patients with traumatic brain injury need further optimization. For patients with cardiac arrest, extracorporeal cardiopulmonary resuscitation can reduce in-hospital mortality and improve long-term neurological prognosis. For neurocritical care patients, abundant high-quality studies have emerged in areas including multimodal neuromonitoring, hemodynamic management, airway management and respiratory therapy, and antiepileptic treatment. In 2023, the guidelines for aSAH have been updated for the first time in the past decade, aiming to provide evidence-based practice recommendations for clinical care. Chinese expert consensuses have also been formulated to guide analgesia and sedation for neurocritical care patients and developed a set of medical quality indicators on neurocritical care, which will enhance standardization and homogenization improvement in neurocritical care quality.

摘要

本综述总结了神经重症监护领域当前的研究进展和指南更新情况。对于缺血性卒中的治疗,血管内血栓切除术延长的治疗时间窗以及新型溶栓药物和策略的出现为患者康复带来了更大希望。微创血肿清除术和目标导向的捆绑式管理在治疗脑出血方面已显示出临床益处。在动脉瘤性蛛网膜下腔出血(aSAH)的治疗中,早期腰大池引流可降低梗死风险。重度创伤性脑损伤的去骨瓣减压术也获得了高质量证据支持。然而,创伤性脑损伤患者的多模态脑监测策略需要进一步优化。对于心脏骤停患者,体外心肺复苏可降低院内死亡率并改善长期神经预后。对于神经重症监护患者,在多模态神经监测、血流动力学管理、气道管理和呼吸治疗以及抗癫痫治疗等领域已出现了大量高质量研究。2023年,aSAH指南在过去十年中首次更新,旨在为临床护理提供循证实践建议。中国专家也已达成共识,以指导神经重症监护患者的镇痛和镇静,并制定了一套神经重症监护医疗质量指标,这将提高神经重症监护质量的标准化和同质化水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb5d/11763594/723dbb74a122/gr1.jpg

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