Lanfredi Mariangela, Meloni Serena, Ferrari Clarissa, Fruzzetti Alan E, Geviti Andrea, Macis Ambra, Vanni Giovanna, Perna Giampaolo, Diaferia Giuseppina, Pinti Maddalena, Occhialini Giorgia, Ridolfi Maria Elena, Rossi Roberta
Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Research and Clinical Trials Office, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Fam Process. 2025 Mar;64(1):e13098. doi: 10.1111/famp.13098.
Borderline personality disorder (BPD) has a strong impact not only on patients' lives but also on their families. The presence of an invalidating environment is one of the key factors in the etiology of BPD. This study evaluated the impact of the Family connections (FC) program on burden, grief, and other clinical variables in 202 caregivers and identified the profiles of participants who improved/deteriorated their levels of burden and grief. Findings from generalized linear mixed models showed significant reductions in burden, grief, depression, global psychological distress, and suppressed and expressed anger after FC intervention. Two classification trees were applied to test whether improvements in burden and grief were associated with age, gender and the improvements in other clinical variables. Caregivers reporting reduced depression were more likely to improve in both burden and grief. Moreover, younger participants showing increased depression had a 72.7% probability of being part of the improvement in burden and a 66.7% probability of being part of the improvement in grief. A decrease in depression and having a younger age were associated with positive gains for caregiving burden and grief. Longitudinally, ANOVAs showed positive changes in burden and grief as well as decreased depression, global psychological distress and suppressed anger were maintained at 4-month follow-up. Present findings improve our understanding of the utility of the FC program for caregivers of people with BPD. The impact of depressive symptoms' reduction and being younger on perceived burden and grief highlight the importance of exploring additional possible moderators of outcomes in FC intervention. Trial Registration: NCT06076343; NCT06074289. Registered 10/10/2023.
边缘性人格障碍(BPD)不仅对患者的生活有重大影响,对其家庭也是如此。无效环境的存在是BPD病因的关键因素之一。本研究评估了家庭联系(FC)项目对202名照料者的负担、悲伤及其他临床变量的影响,并确定了负担和悲伤水平得到改善或恶化的参与者特征。广义线性混合模型的结果显示,FC干预后,照料者的负担、悲伤、抑郁、总体心理困扰以及压抑和表达的愤怒均显著减轻。应用两棵分类树来检验负担和悲伤的改善是否与年龄、性别以及其他临床变量的改善有关。报告抑郁减轻的照料者在负担和悲伤方面更有可能得到改善。此外,抑郁症状加重的年轻参与者在负担改善方面的概率为72.7%,在悲伤改善方面的概率为66.7%。抑郁减轻和年龄较小与照料负担和悲伤的积极改善相关。纵向来看,方差分析显示,在4个月的随访中,负担和悲伤方面的积极变化以及抑郁、总体心理困扰和压抑愤怒的减轻得以维持。目前的研究结果增进了我们对FC项目对照料BPD患者的照料者的效用的理解。抑郁症状减轻和年龄较小对感知负担和悲伤的影响凸显了探索FC干预中其他可能的结果调节因素的重要性。试验注册:NCT06076343;NCT06074289。于2023年10月10日注册。