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边缘型人格障碍患者家庭成员的家庭关系与优化常规治疗对比:非随机对照研究

Family Connections versus optimised treatment-as-usual for family members of individuals with borderline personality disorder: non-randomised controlled study.

作者信息

Flynn Daniel, Kells Mary, Joyce Mary, Corcoran Paul, Herley Sarah, Suarez Catalina, Cotter Padraig, Hurley Justina, Weihrauch Mareike, Groeger John

机构信息

Cork Mental Health Services, Health Service Executive, Block 2, St Finbarr's Hospital, Cork, Ireland.

National Suicide Research Foundation, Western Gateway Building, University College Cork, Cork, Ireland.

出版信息

Borderline Personal Disord Emot Dysregul. 2017 Aug 30;4:18. doi: 10.1186/s40479-017-0069-1. eCollection 2017.

Abstract

BACKGROUND

Borderline personality disorder (BPD) is challenging for family members who are often required to fulfil multiple roles such as those of advocate, caregiver, coach and guardian. To date, two uncontrolled studies by the treatment developers suggest that Family Connections (FC) is an effective programme to support, educate and teach skills to family members of individuals with BPD. However, such studies have been limited by lack of comparison to other treatment approaches. This study aimed to compare the effectiveness of FC with an optimised treatment-as-usual (OTAU) programme for family members of individuals with BPD. A secondary aim was to introduce a long term follow-up to investigate if positive gains from the intervention would be maintained following programme completion.

METHODS

This study was a non-randomised controlled study, with assessment of outcomes at baseline (pre-intervention) and end of programme (post-intervention) for both FC and OTAU groups, and at follow-up (3 months post-intervention; 12 or 19 months post-intervention) for the FC group. Eighty family members participated in the FC ( = 51) and the OTAU ( = 29) programmes. Outcome measures included burden, grief, depression and mastery. Linear mixed-effects models were used to assess baseline differences in the outcome measures by gender, age group and type of relationship to the individual with BPD. Linear mixed-effects models were also used to estimate the treatment effect (FC versus OTAU) utilising all available data from baseline and end of programme.

RESULTS

The FC group showed changes indicating significant improvement with respect to all four outcome measures ( < 0.001). The OTAU group showed changes in the same direction as the intervention group but none of the changes were statistically significant. The intervention effect was statistically significant for total burden (including both subscales;  = .02 for subjective burden and  = .048 for objective burden) and grief ( = 0.013). Improvements were maintained at follow-up for FC participants.

CONCLUSIONS

The findings of the current study indicate that FC results in statistically significant improvements on key measures while OTAU does not yield comparable changes. Lack of significant change on all measures for OTAU suggests that a three session psycho-education programme is of limited benefit. Further research is warranted on programme components and long-term supports for family members.

摘要

背景

边缘性人格障碍(BPD)对于家庭成员来说颇具挑战,他们常常需要扮演多种角色,如支持者、照顾者、指导者和监护人。迄今为止,治疗开发者进行的两项非对照研究表明,家庭联系(FC)是一项有效的项目,可为BPD患者的家庭成员提供支持、教育并教授技能。然而,此类研究因缺乏与其他治疗方法的比较而受到限制。本研究旨在比较FC与优化常规治疗(OTAU)项目对BPD患者家庭成员的有效性。第二个目标是引入长期随访,以调查干预带来的积极效果在项目结束后是否会持续。

方法

本研究为非随机对照研究,对FC组和OTAU组在基线(干预前)和项目结束时(干预后)进行结果评估,对FC组在随访时(干预后3个月;干预后12或19个月)进行结果评估。80名家庭成员参与了FC(n = 51)和OTAU(n = 29)项目。结果测量包括负担、悲伤、抑郁和掌控感。线性混合效应模型用于评估按性别、年龄组以及与BPD患者的关系类型划分的结果测量的基线差异。线性混合效应模型还用于利用来自基线和项目结束时的所有可用数据估计治疗效果(FC与OTAU)。

结果

FC组在所有四项结果测量方面均显示出表明显著改善的变化(P < 0.001)。OTAU组显示出与干预组相同方向的变化,但没有一项变化具有统计学意义。干预效果在总负担(包括两个子量表;主观负担P = 0.02,客观负担P = 0.048)和悲伤方面具有统计学意义(P = 0.013)。FC参与者在随访时维持了改善。

结论

本研究结果表明,FC在关键测量指标上带来了具有统计学意义的改善,而OTAU并未产生类似的变化。OTAU在所有测量指标上均未出现显著变化,这表明一个为期三节的心理教育项目益处有限。有必要对项目组成部分以及对家庭成员的长期支持进行进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e42/5575921/1f4a8dba6d76/40479_2017_69_Fig1_HTML.jpg

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