Martínez-Lazaro Rebeca, Reyes-Carrión Andrea, Bartolomé-Martín David, Giraldez Teresa
Departamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud-sección Medicina, Universidad de La Laguna, Tenerife, ES-38071, Spain.
Instituto de Tecnologías Biomédicas, Universidad de La Laguna, Tenerife ES-38071, Spain.
Biochem Soc Trans. 2025 Jan 28;53(1):BST20240425. doi: 10.1042/BST20240425.
Large conductance voltage- and calcium-activated potassium channels (BK channels) are extensively found throughout the central nervous system and play a crucial role in various neuronal functions. These channels are activated by a combination of cell membrane depolarisation and an increase in intracellular calcium concentration, provided by calcium sources located close to BK. In 2001, Isaacson and Murphy first demonstrated the coupling of BK channels with N-methyl-D-aspartate receptors (NMDAR) in olfactory bulb neurons. Since then, additional evidence has confirmed this functional coupling in other brain regions and highlighted its significance in neuronal function and pathophysiology. In this review, we explore the current understanding of these macrocomplexes in the brain, the molecular mechanisms behind their interactions and their potential roles in neurodevelopmental disorders, paving the way for new treatment strategies.
大电导电压和钙激活钾通道（BK通道）广泛存在于整个中枢神经系统中，并在各种神经元功能中发挥关键作用。这些通道由细胞膜去极化和细胞内钙浓度升高共同激活，钙源位于BK通道附近。2001年，艾萨克森和墨菲首次证明BK通道与嗅球神经元中的N-甲基-D-天冬氨酸受体（NMDAR）偶联。从那时起，更多证据证实了这种功能偶联在其他脑区的存在，并突出了其在神经元功能和病理生理学中的重要性。在这篇综述中，我们探讨了目前对大脑中这些大分子复合物的理解、它们相互作用背后的分子机制以及它们在神经发育障碍中的潜在作用，为新的治疗策略铺平道路。
