Echeverría Felipe, Gonzalez-Sanabria Naileth, Alvarado-Sanchez Rosangelina, Fernández Miguel, Castillo Karen, Latorre Ramon
Centro Interdisciplinario de Neurociencia de Valparaíso, Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.
Centro de Investigación de Estudios Avanzados del Maule, Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca, Chile.
Front Pharmacol. 2024 Mar 22;15:1373507. doi: 10.3389/fphar.2024.1373507. eCollection 2024.
Large Conductance Voltage- and Calcium-activated K (BK) channels are transmembrane pore-forming proteins that regulate cell excitability and are also expressed in non-excitable cells. They play a role in regulating vascular tone, neuronal excitability, neurotransmitter release, and muscle contraction. Dysfunction of the BK channel can lead to arterial hypertension, hearing disorders, epilepsy, and ataxia. Here, we provide an overview of BK channel functioning and the implications of its abnormal functioning in various diseases. Understanding the function of BK channels is crucial for comprehending the mechanisms involved in regulating vital physiological processes, both in normal and pathological conditions, controlled by BK. This understanding may lead to the development of therapeutic interventions to address BK channelopathies.
大电导电压和钙激活钾（BK）通道是调节细胞兴奋性的跨膜孔形成蛋白，也在非兴奋性细胞中表达。它们在调节血管张力、神经元兴奋性、神经递质释放和肌肉收缩中发挥作用。BK通道功能障碍可导致动脉高血压、听力障碍、癫痫和共济失调。在此，我们概述了BK通道的功能及其在各种疾病中异常功能的影响。了解BK通道的功能对于理解在正常和病理条件下由BK控制的重要生理过程的调节机制至关重要。这种理解可能会导致开发针对BK通道病的治疗干预措施。
